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glipizide, Glipizide XL, Glucotrol: Drug Side Effects

What is glipizide, and how does it work (mechanism of action)?

Glipizide is an oral drug that is used for treating patients with
type 2 diabetes. It belongs to the sulfonylurea class of drugs which also includes glimepiride (Amaryl), glyburide (Diabeta, Glynase), tolbutamide and tolazamide. Insulin is a hormone that is made in the pancreas that when released into the blood causes cells in the body to remove sugar (glucose) from the blood and reduces the formation of glucose by the liver. Patients with type 2 diabetes have high glucose (sugar) levels in their blood because the cells in their bodies are resistant to the glucose-removing effect of the insulin, and the liver produces too much glucose. In addition, in type 2 diabetes the pancreas is unable to produce the increased amounts of insulin that are necessary to overcome the resistance. Glipizide reduces blood glucose by stimulating the pancreas to produce more insulin.

Glipizide is not a cure for diabetes.

The FDA approved glipizide in May 1984.

What brand names are available for glipizide?

Glipizide XL, Glucotrol, Glucotrol XL

Is glipizide available as a generic drug?


Do I need a prescription for glipizide?


What are the side effects of glipizide?

Side effects include:






heartburn, and


Skin rashes can occur and cause itching, hives, or a diffuse
measles-like rash.

Rare but serious side effects include:

Glipizide also may cause hypoglycemia. The risk of hypoglycemia increases when glipizide is combined with other glucose reducing agents.

What is the dosage for glipizide?

  • The usual starting dose when using immediate release tablets is 5 mg daily administered 30 minutes before a meal.
  • The maximum dose is 40 mg daily.
  • Doses higher than 15 mg per day should be divided and given in divided doses daily.
  • The starting dose when using extended-release tablets is 5 mg daily up to a maximum dose of 20 mg daily.
  • Patients using immediate release tablets may be converted to the nearest equivalent extended-release dose.

Which drugs or supplements interact with glipizide?


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Is glipizide safe to take if I’m pregnant or breastfeeding?

Studies of adverse effects in animal studies indicate that glipizide crosses the placenta. It is not recommended to use glipizide for the routine management of diabetes in pregnant women. Insulin is preferred. In the event that glipizide is used during pregnancy, the manufacturer recommends that it be stopped at least 1 month before the expected date of delivery.

According to reports, glipizide is not found in breast milk. However, the risk of developing hypoglycemia in the nursing infant should be weighed against the potential benefit to the monther of taking glipizide and a decision should be made to discontinue the drug or to discontinue

What else should I know about glipizide?

What preparations of glipizide are available?

: Immediate-release tablets; 5 and 10 mg. Extended-release tablets; 2.5, 5, and 10 mg.

How should I keep glipizide stored?

Glipizide should be stored between 15 C and 30 C (59 F and 86 F).


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