Prednisone Side Effects, Dosage, Uses & Withdrawal Symptoms

What is prednisone, and how does it work?

Prednisone is an oral, synthetic (man-made) corticosteroid (steroid) used for suppressing the immune system and inflammation. It has effects similar to other corticosteroids such as:

triamcinolone (Kenacort)
methylprednisolone (Medrol)
prednisolone (Prelone)
dexamethasone (Decadron)

These synthetic corticosteroids mimic the action of cortisol (hydrocortisone), the naturally-occurring corticosteroid produced in the body by the adrenal glands. Corticosteroids have many effects on the body, but they most often are used for their potent anti-inflammatory effects, particularly in those diseases and conditions in which the immune system plays an important role, for example, arthritis, colitis, asthma, bronchitis, skin problems, and allergies. Prednisone is inactive in the body and, in order to be effective, first must be converted to prednisolone by enzymes in the liver. Therefore, prednisone may not work as effectively in people with liver disease whose ability to convert prednisone to prednisolone is impaired. The FDA approved prednisone in 1955.

What diseases and conditions does prednisone treat (uses)?

Prednisone is used in the management of inflammatory conditions or diseases in which the immune system plays an important role. Since this drug is used for the treatment and management of so many diseases and conditions, only the most common or FDA approved uses are listed.

Several types of arthritis
Ulcerative colitis
Crohn's disease
Systemic lupus
Allergic reactions
Asthma
Severe psoriasis

It also is used the treatment of:

Corticosteroids, including prednisone, are commonly used to suppress the immune system and prevent the body from rejecting transplanted organs.

Prednisone is used as replacement therapy in patients whose adrenal glands are unable to produce sufficient amounts of cortisol.

What is the dosage for prednisone, and how should it be taken?

The initial dosage of prednisone varies depending on the condition being treated and the age of the patient.

It's recommended that you take this medication with food.
The starting dose may be from 5 mg to 60 mg per day, and often is adjusted based on the response of the disease or condition being treated.
Corticosteroids typically do not produce immediate effects and must be used for several days before maximal effects are seen. It may take much longer before conditions respond to treatment.
When prednisone is discontinued after a period of prolonged therapy, the dose of prednisone must be tapered (lowered gradually) to allow the adrenal glands time to recover.

How should prednisone be tapered, and what are the withdrawal symptoms and signs?

Patients should be slowly weaned off prednisone. Abrupt withdrawal of prednisone after prolonged use causes side effects because the adrenal glands are unable to produce enough cortisol to compensate for the withdrawal, and symptoms of corticosteroid insufficiency (adrenal crisis) may occur. These symptoms include:

Therefore, weaning off prednisone should occur gradually so that the adrenal glands have time to recover and resume production of cortisol. Until the glands fully recover, it may be necessary to treat patients who have recently discontinued corticosteroids with a short course of corticosteroids during times of stress (infection, surgery, etc.), times when corticosteroids are particularly important to the body.

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Which drugs or supplements interact with prednisone?

Prednisone interacts with many drugs, examples include:

Prednisone may interact with estrogens and phenytoin (Dilantin). Estrogens may reduce the action of enzymes in the liver that break down (eliminate) the active form of prednisone, prednisolone. As a result, the levels of prednisolone in the body may increase and lead to more frequent side effects.
Phenytoin increases the activity of enzymes in the liver that break down (eliminate) prednisone and thereby may reduce the effectiveness of prednisone. Thus, if phenytoin is being taken, an increased dose of prednisone may be required.
The risk of hypokalemia (high potassium levels in the blood) increases when corticosteroids are combined with drugs that reduce potassium levels (for example, amphotericin B, diuretics), leading to serious side effects such as heart enlargement, heart arrhythmias and congestive heart failure.
Corticosteroids may increase or decrease the response warfarin (Coumadin, Jantoven). Therefore, warfarin therapy should be monitored closely.
The response to diabetes drugs may be reduced because prednisone increases blood glucose.
Prednisone may increase the risk of tendon rupture in patients treated with fluoroquinolone type antibiotics. Examples of fluoroquinolones include ciprofloxacin (Cipro) and levofloxacin (Levaquin).
The elderly are especially at risk and tendon rupture may occur during or after treatment with fluoroquinolones.
Combining aspirin, ibuprofen (Motrin) or other nonsteroidal anti-inflammatory agents (NSAIDS) with corticosteroids increases the risk of stomach related side effects like ulcers.
Barbiturates, carbamazepine, rifampin and other drugs that increase the activity of liver enzymes that breakdown prednisone may reduce blood levels of prednisone. Conversely, ketoconazole, itraconazole (Sporanox), ritonavir (Norvir), indinavir (Crixivan), macrolide antibiotics such as erythromycin, and other drugs that reduce the activity of liver enzymes that breakdown prednisone may increase blood levels of prednisone.

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Is it safe to take prednisone over a long period of time?

No, prolonged therapy with prednisone causes the adrenal glands to atrophy and stop producing cortisol.

Is this drug safe to take if I’m pregnant or breastfeeding?

Corticosteroids cross the placenta into the fetus. Compared to other corticosteroids, however, prednisone is less likely to cross the placenta. Chronic use of corticosteroids during the first trimester of pregnancy may cause cleft palate.
Corticosteroids are secreted in breast milk and can cause side effects in the nursing infant. Prednisone is less likely than other corticosteroids to be secreted in breast milk, but it may still pose a risk to the infant.

What brand names are available for prednisone?

Prednisone Intensol, Rayos

What else should I know about this medicine?

Prednisone is available as:

Tablets of 1, 2.5, 10, 20, and 50 mg.
Extended Release Tablets of 1, 2, and 5 mg.
Oral solution or syrup of 5mg/5ml

Keep this drug stored at room temperature 20 C -25 C (68 F -77 F), and keep away from moisture.