Diflucan (fluconazole) Side Effects (Alcohol), Dosage & Pregnancy

Diflucan (fluconazole) is an anti-fungal medication related to clotrimazole (Lotrimin), ketoconazole (Nizoral), itraconazole (Sporanox), and miconazole (Micatin, Monistat). Fluconazole prevents growth of fungi by preventing production of the membranes that surround fungal cells.

Diflucan is used for treating vaginal, oral, and esophageal fungal infections caused by Candida. It is used for treating uncomplicated, complicated, or recurrent vaginal Candida infections.
Diflucan also may be effective in treating urinary tract infections, peritonitis, pneumonia and disseminated infections caused by Candida.
Diflucanis used for treating cryptococcal meningitis, and prevention of Candida infections in patients treated with chemotherapy or radiation after bone marrow transplantation.

Common side effects of fluconazole include

Other important side effects include

Possible serious side effects include

Rarely, serious allergic reactions, including angioedema (swelling of tissues), may also occur. Liver dysfunction (jaundice, hepatitis) and abnormal heart beats have been associated with fluconazole. Stevens-Johnson syndrome has also been reported.

The usual adult dose is 50-400 mg daily depending on the type of infection. Although symptoms of oral Candida infections may subside in a few days, treatment is continued for 2 weeks.
Esophageal Candida infections are treated for 3 weeks or longer.
Treatment of cryptococcal meningitis may last for 10-12 weeks after cerebrospinal fluid cultures become negative.

Hydrochlorothiazide increases the blood concentration of fluconazole by 40%. However, dosage modification is not recommended when both drugs are combined.
Rifampin (Rifadin, Rimactane, Rifadin, Rifater, Rifamate) reduces the blood concentration of oral fluconazole, probably by increasing the elimination of fluconazole in the liver; therefore, reducing the effectiveness of fluconazole.
Fluconazole may increase the concentration of warfarin (Coumadin, Jantoven) in blood by reducing the elimination of warfarin. Therefore, the effect of warfarin may increase, leading to an increased tendency to bleed.
Fluconazole also increases the concentration of the following drugs in the blood, and as a result, the risk of side effects of these drugs may increase. These drugs include:
- phenytoin (Dilantin),
- cyclosporine,
- zidovudine (Retrovir),
- saquinavir (Invirase),
- theophylline (Theo-Dur, Respbid, Slo-Bid, Theo-24, Theolair, Uniphyl, Slo-Phyllin),
- tolbutamide,
- glyburide (Micronase, Diabeta, Glynase),
- glipizide,
- triazolam (Glucotrol),
- midazolam (Versed),
- celecoxib (Celebrex),
- fentanyl (Sublimaze),
- atorvastatin (Lipitor),
- simvastatin (Zocor), and
- lovastatin (Mevacor).
As a result, the risk of side effects from the above drugs may increase.
Combining fluconazole with amiodarone (Cordarone), pimozide (Orap), bepridil (Vascor) or other drugs that affect heart rhythm may increase the risk of abnormal heart rhythms.

There are no adequate studies of Diflucan in pregnant women. There are reports of harmful effects to the fetus when high dose fluconazole was administered to pregnant women for a few months. Use of fluconazole during pregnancy is not recommended.
Diflucan is secreted in breast milk at concentrations similar to the mother's blood level. However, fluconazole is used for treating neonates with fungal infections and for treating lactation associated Candida infections. Available evidence suggests that use of fluconazole during breastfeeding has little risk.

Tablets and dry powder should be stored below 86 F (30 C).Injection and reconstituted suspension should be stored between 5 C and 30 C (41 F and 86 F).
Unused portions of the reconstituted suspension should be protected from freezing and discarded after 2 weeks.

Diflucan is available in generic form. You need a prescription ffor Diflucan from your doctor.