Angiotensin II Receptor Blockers (ARBs) vs. Calcium Channel Blockers (CCBs)

Angiotensin II receptor blockers vs. calcium channel blockers: What’s the difference?

What are Angiotensin II Receptor Blockers (ARBs)? What are Calcium Channel Blockers (CCBs)?

Angiotensin II receptor blockers (ARBs) are used to control high blood pressure, treat heart failure, and prevent kidney failure in people with diabetes or high blood pressure. ARBs also may prevent diabetes and reduce the risk of stroke in patients with high blood pressure and an enlarged heart, and they may also prevent the recurrence of atrial fibrillation. Angiotensin II is a potent chemical formed in the blood that causes muscles surrounding blood vessels to contract, narrowing the vessels. This narrowing increases pressure within the vessels and can cause high blood pressure (hypertension). Angiotensin II receptor blockers (ARBs) work by preventing angiotensin II from binding to angiotensin II receptors on the muscles surrounding blood vessels so blood vessels enlarge (dilate) and blood pressure is reduced.

Calcium channel blockers (CCBs) are used to treat high blood pressure, angina (chest pain), and abnormal heart rhythms. They also may be used after a heart attack. Calcium channel blockers dilate the arteries, which reduces pressure in the arteries and makes it easier for the heart to pump blood. As a result, the heart needs less oxygen, which can relieve or prevent angina. CCBs are also used to treat high blood pressure and certain types of abnormally rapid heart rhythms.


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What are the side effects of ARBs and CCBs?


ARBs are well tolerated by most people. The most common side effects are

Compared to ACE inhibitors, cough occurs less often with ARBs.

  • Serious side effects of ARBs
  • • The most serious, but rare, side effects are
  • o kidney failure,
  • o liver failure (hepatitis),
  • o serious allergic reactions,
  • o a decrease in white blood cells,
  • o a decrease in blood platelets, and
  • o swelling of tissues (angioedema).
  • • There have been reports of rhabdomyolysis (destruction of skeletal muscle) in patients receiving ARBs.
  • • Individuals who have narrowing of both arteries that supply the kidneys or have had a severe reaction to ARBs should avoid them.
  • • Like other antihypertensives, ARBs have been associated with sexual dysfunction.


The most common side effects of calcium channel blockers are:

Liver dysfunction and over growth of the gums also occurs.

When diltiazem (Cardizem) or verapamil (Calan, Isoptin) are given to individuals with heart failure, symptoms of heart failure may worsen because these drugs reduce the ability of the heart to pump blood.

Like other blood pressure medications, calcium channel blockers are associated with sexual dysfunction.

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What drugs interact with ARBs and CCBs?


  • ARBs have few interactions with other drugs.
  • Since ARBs may increase blood levels of potassium, the use of potassium supplements, salt substitutes (which often contain potassium), or other drugs that increase potassium may result in excessive blood potassium levels and cardiac arrhythmias.
  • ARBs may also increase the blood concentration of lithium (Eskalith, Lithobid) and lead to an increase in side effects from lithium.
  • Rifampin (Rifadin) reduces the blood levels of losartan, and fluconazole (Diflucan) reduces the conversion of losartan to its active form. These effects could decrease the effects of losartan.
  • ARBs should not be combined with ACE inhibitors because such combinations increase the risk of hypotension, hyperkalemia, and renal impairment.
  • ARBs should not be combined with aliskiren (Tekturna) because such combinations increase the risk of kidney failure, excessive low blood pressure, and hyperkalemia.


Most of the interactions of calcium channel blockers occur with verapamil (Calan, Isoptin) or diltiazem (Cardizem). The interaction occurs because verapamil and diltiazem decrease the elimination of a number of drugs by the liver. Through this mechanism, verapamil and diltiazem may reduce the elimination and increase the blood levels of carbamazepine (Tegretol), simvastatin (Zocor), atorvastatin (Lipitor), and lovastatin (Mevacor). This can lead to toxicity from these drugs.

Grapefruit juice (approximately 200 ml) may elevate blood concentrations of felodipine (Plendil), verapamil (Calan, Isoptin), nisoldipine (Sular), nifedipine (Adalat, Procardia), nicardipine (Cardene), and possibly amlodipine (Norvasc). Grapefruit juice should not be consumed within 2 hours before or 4 hours after administration of affected calcium channel blockers.

What are the different types of ARBs and CCBs?


The ARBs that are currently available are:

  • azilsartan (Edarbi)
  • candesartan (Atacand)
  • eprosartan (Teveten)
  • irbesartan (Avapro)
  • telmisartan (Micardis)
  • valsartan (Diovan, Prexxartan)
  • losartan (Cozaar)
  • olmesartan (Benicar)
  • entresto (sacubitril/valsartan)
  • byvalson (nebivolol/valsartan)

ARBs are similar in actions and side effects. They differ in how they are eliminated from the body and the extent to which they are distributed throughout the body.

  • Some ARBs need to be converted to an active form in the body before they can lower blood pressure. In addition, some ARBs are better at lowering blood pressure.
  • In some studies, irbesartan (Avapro) and candesartan (Atacand) reduced blood pressure better than losartan (Cozaar).


The calcium channel blockers that have been approved for use in the US include:

  • amlodipine (Norvasc)
  • amlodipine and atorvastatin (Caduet)
  • amlodipine and benazepril (Lotrel)
  • amlodipine and valsartan (Exforge)
  • amlodipine and telmisartan (Twynsta)
  • amlodipine and olmesartan (Azor)
  • amlodipine and olmesartan and hydroclorothiazide (Tribenzor)
  • amlodipine and aliskiren and hydroclorothiazide
  • amlodipine and perindopril (Prestalia)
  • clevidipine (Cleviprex)
  • diltiazem (Cardizem)
  • felodipine (Cardene, Cardene SR)
  • isradipine
  • nicardipine
  • nimodipine
  • nisoldipine (Sular)
  • verapamil (Calan)

Calcium channel blockers differ in their duration of action, the process by which they are eliminated from the body, and, most importantly, in their ability to affect heart rate and contraction. Some calcium channel blockers (for example, amlodipine [Norvasc]) have very little effect on heart rate and contraction so they are safer to use in individuals who have heart failure or bradycardia (a slow heart rate). Verapamil (Calan, Isoptin) and diltiazem (Cardizem) have the greatest effects on the heart and reduce the strength and rate of contraction. Therefore, they are used in reducing heart rate when the heart is beating too fast.

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