What are the uses for amlodipine and benazepril?
Lotrel is used for treating high blood pressure
(hypertension) when blood pressure is not adequately controlled with either of
its constituent drugs alone.
What brand names are available for amlodipine and benazepril?
Lotrel
Is amlodipine and benazepril available as a generic drug?
Yes
Do I need a prescription for amlodipine and benazepril?
Yes
What are the side effects of amlodipine and benazepril?
Lotrel causes the same side effects as benazepril and amlodipine.
Common side of Lotrel include
- water retention (edema) in legs and arms,
- edema in the lungs
- stomach pain,
- nausea,
- dizziness,
- fatigue,
- headache,
- muscle cramps,
- sexual problems, and
- drowsiness.
Other side effects of Lotrel include
- kidney failure,
- indigestion,
- blood disorders,
- overgrowth of gums,
-
heart
palpitations, - anemia,
- reduced
number of platelets in the blood, and - serious skin reactions also may occur.
QUESTION
Salt and sodium are the same.
See Answer
What is the dosage for amlodipine and benazepril?
The dose of Lotrel is tailored to the patient's needs. The
dose is one capsule once daily.
Which drugs or supplements interact with amlodipine and benazepril?
- Combining benazepril with potassium
supplements,
potassium containing salt substitutes, and potassium conserving diuretics such
as amiloride (Moduretic),
spironolactone (Aldactone), and
triamterene (Dyazide,
Maxzide), can lead to dangerously high blood levels of potassium. - There have
been reports of increased
lithium (Eskalith,
Lithobid) levels when lithium is
used in combination with
ACE inhibitors. The reason for this interaction is not
known, but the increased levels may lead to toxicity from lithium. - There have
been reports that
aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs)
such as
ibuprofen (Advil, Children's Advil/Motrin, Medipren, Motrin,
Nuprin,
PediaCare
Fever, etc.),
indomethacin (Indocin,
Indocin-SR), and
naproxen (Anaprox,
Naprelan,
Naprosyn,
Aleve) may reduce the effects of ACE inhibitors. Combining
ACE inhibitors with NSAIDs in patients who are elderly, volume-depleted
(including those on diuretic therapy), or with poor kidney function may result
in reduced kidney function, including
kidney failure. These effects usually are
reversible. - Nitritoid reactions (symptoms include facial flushing,
nausea,
vomiting and
low blood pressure or
hypotension) may occur when injectable gold
(sodium aurothiomalate), used in the treatment of
rheumatoid arthritis, is
combined with ACE inhibitors. - Amlodipine increases blood levels of
simvastatin (Zocor).
The dose of simvastatin should be limited to 20 mg daily when combined with
amlodipine.
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Is amlodipine and benazepril safe to take if I’m pregnant or breastfeeding?
- ACE inhibitors, including benazepril, can be harmful to the
fetus and should not be taken by pregnant women. - Small amounts of benazepril are excreted in
breast
milk. It is not known whether amlodipine is excreted in breast milk. Lotrel or
nursing should be discontinued.
What else should I know about amlodipine and benazepril?
What preparations of amlodipine and benazepril are available?
Capsules (mg amlodipine/mg benazepril): 2.5/10;
5/10;5/20; 5/40; 10/20; and 10/40
How should I keep amlodipine and benazepril stored?
Lotrel should be stored at room temperature, 15 C – 30 C (59 C – 86 F).