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felodipine (Plendil) Side Effects, Dosage & Interactions

What is felodipine, and how does it work?

Felodipine is an oral calcium channel blocker
(CCB) of the dihydropyridine (DHP) class. Other

calcium channel blockers in the DHP class include:

Calcium is necessary for muscle cells to contract. Felodipine prevents calcium
from being released within the muscle cells of the small arteries and thereby
causes the muscles to relax and the arteries to dilate or expand.

Dilation of arteries reduces

blood pressure.
It has little or no effect on the muscles of veins
or the heart.

What brand names are available for felodipine?

Plendil is the brand name available for this drug in the US.

What is felodipine used for?

What are the side effects of felodipine?

The most common side effects reported by patients include:

Other important side effects include:

What is the dosage for felodipine?

  • The recommended dose of felodipine is 2.5-10 mg once daily.
  • It should
    be taken without food or with no more than a light meal since food may reduce
    its absorption.
  • Since felodipine comes as a sustained-release tablet, it should
    be swallowed whole. It should not be chewed or crushed.


Salt and sodium are the same.
See Answer

Which drugs, supplements, or foods interact with felodipine?

  • Cimetidine (Tagamet),
    ketoconazole (Nizoral,
    itraconazole (Sporanox),
    and erythromycin
    can block the breakdown of felodipine, resulting in higher blood concentrations
    of felodipine and drops in blood pressure.
  • Carbamazepine
    phenobarbital, or
    phenytoin (Dilantin)
    can lower felodipine blood concentrations. Therefore, higher doses of felodipine
    may be necessary in patients receiving these medications.
  • Taking felodipine with grapefruit juice increases its absorption and may lead
    to sudden drops in blood pressure.
  • Felodipine may increase blood concentrations
    of tacrolimus (Prograf).
    Tacrolimus blood concentrations should be monitored and the dose should be
    modified as necessary.

Is it safe to take if I'm pregnant or breastfeeding?

  • There aren't any adequate studies on the effects of felodipine in ppregnant women.
    Animal studies have shown adverse effects. Therefore, your doctor or health
    care professional must weigh the potential risks to the fetus against the potential
    benefits to the you.
  • We don't know if felodipine is excreted in breast milk.

What else should I know about this drug?

  • It’s available as tablets (extended Release) in 2.5, 5, and 10 mg
  • You should keep the tablets stored below 86 F (30 C) and protect them from light and moisture.
  • Felodipine was approved by the FDA in 1991.

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