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guaifenesin, phenylephrine (Sudafed PE Non-Drying Sinus Caplets)

What is guaifenesin, phenylephrine, and how does it work (mechanism of action)?

Guaifenesin/phenylephrine is a medication that
contains two different drugs, an expectorant (guaifenesin) and a decongestant
(phenylephrine). The expectorant effects of guaifenesin promote drainage of
mucus from the lungs by thinning the mucus. It also lubricates the irritated
respiratory tract. Phenylephrine relieves stuffy nose by constricting blood
vessels in the nasal air passages. This reduces the flow of fluid out of the
blood vessels and into the tissues of the air passages.

What brand names are available for guaifenesin, phenylephrine?

Sudafed PE Non-Drying
Sinus Caplets, (Entex, discontinued)

Is guaifenesin, phenylephrine available as a generic drug?


Do I need a prescription for guaifenesin, phenylephrine?


What are the side effects of guaifenesin, phenylephrine?

Side effects of guaifenesin/phenylephrine and include stimulation
of the nervous system leading to nervousness, restlessness, excitability,
dizziness, headache, fear, anxiety,
tremor, and even
hallucinations and convulsions (seizures). Nausea, vomiting, and rash also

What is the dosage for guaifenesin, phenylephrine?

Guaifenesin/phenylephrine may be taken with or without food. It must
be used cautiously in patients with heart (coronary artery) disease and
angina, and

Which drugs or supplements interact with guaifenesin, phenylephrine?

Guaifenesin/phenylephrine should not be taken with MAO
inhibitors drugs due to the increased risk of serious adverse effects


Which illness is known as a viral upper respiratory tract infection?
See Answer

Is guaifenesin, phenylephrine safe to take if I’m pregnant or breastfeeding?

Phenylephrine can cause
birth defects
in some animal species. Additionally, there have been associations between first
trimester exposure to these medications and malformations, primarily minor
malformations. Although one analysis found a correlation between guaifenesin use
in the first trimester of pregnancy and an increased risk of
others found no increased risk of malformations. Thus, guaifenesin/phenylephrine
should be used in pregnancy only if the physician feels that the potential
benefits outweigh the potential risks.

Small amounts of phenylephrine is excreted in
breast milk.

What else should I know about guaifenesin, phenylephrine?

What preparations of guaifenesin, phenylephrine are available?

Caplet: 5 mg/200 mg

How should I keep guaifenesin, phenylephrine stored?

Store at room temperature below 30 C (86 F).


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