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Pseudoephedrine Cold and Allergy Drug Side Effects & Dosage

What is pseudoephedrine, and how does it work (mechanism of action)?

  • Pseudoephedrine is a decongestant used for reducing nasal congestion caused
    by allergies or the common cold. Pseudoephedrine causes blood vessels in the
    nasal passages to shrink (vasoconstrict). Vasoconstriction reduces nasal
    congestion by preventing fluid from draining from blood vessels into nasal
    passages. Pseudoephedrine also directly stimulates beta-adrenergic receptors and
    causes relaxation of bronchioles, as well as increased heart rate and
  • The FDA approved pseudoephedrine in August 1975.

What brand names are available for pseudoephedrine?

Sudafed, Nexafed, Zephrex-D

Is pseudoephedrine available as a generic drug?


Do I need a prescription for pseudoephedrine?


What are the uses for pseudoephedrine?

  • Pseudoephedrine is used for treating nasal and sinus congestion caused by the
    common cold or allergies.

What are the side effects of pseudoephedrine?

Common side effects of pseudoephedrine include:

Pseudoephedrine should not be used by people with severe hypertension or
coronary artery disease. It should be used with caution in people with mild to
moderate hypertension, cardiac disease, hyperthyroidism, hyperglycemia,
prostatic hyperplasia, diabetes mellitus, kidney problems,
seizure disorder, and


Which illness is known as a viral upper respiratory tract infection?
See Answer

What is the dosage for pseudoephedrine?

  • The recommended dose is 60 mg every 4 to 6 hours when using immediate release
    tablets. When using extended release tablets the recommended dose is 120 mg
    every 12 hours or 240 mg every 24 hours.

Which drugs or supplements interact with pseudoephedrine?

Is pseudoephedrine safe to take if I’m pregnant or breastfeeding?

  • Use of pseudoephedrine by
    pregnant women has not been adequately evaluated.
  • Pseudoephedrine is secreted in breast milk. However, it is considered safe to
    use while nursing.

What else should I know about pseudoephedrine?

What preparations of pseudoephedrine are available?

  • Tablet (immediate-release): 30, 60 mg; Tablet (extended-release): 120, 240 mg

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