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cosyntropin (Cortrosyn): Facts About Drug Side Effects

What is cosyntropin-injectable, and how does it work (mechanism of action)?

Cosyntropin is a manufactured version of the body's natural adrenocorticotropin hormone (ACTH). ACTH is produced by the pituitary gland in the brain. It stimulates the adrenal gland to release steroids including hydrocortisone and cortisone, androgens, as well as aldosterone. Cosyntropin has the same activity as ACTH. The FDA approved Cosyntropin in April 1970.

What brand names are available for cosyntropin-injectable?


Is cosyntropin-injectable available as a generic drug?


Do I need a prescription for cosyntropin-injectable?


What are the side effects of cosyntropin-injectable?

Adverse effects associated with the use of cosyntropin include
slowed heart rate, high blood pressure, edema (fluid buildup) in limbs, and
rapid heartbeat. Other adverse effects include rash as well as redness at the
injection site. Side effects associated with corticosteroid use are also
commonly reported with cosyntropin use. There have been rare reports of
anaphylactic reactions.

What is the dosage for cosyntropin-injectable?

The initial dose for adults is based on what the drug is being used
for and whether it is being given intravenously or intramuscularly. For example,
the intravenous dose in diagnosing adrenocortical insufficiency is 0.25 mg.
Initial doses of 1 mg intramuscularly may be used when transferring from

Which drugs or supplements interact with cosyntropin-injectable?

: Cosyntropin may increase the
electrolyte loss during
diuretic therapy.


What causes tooth decay?
See Answer

Is cosyntropin-injectable safe to take if I’m pregnant or breastfeeding?

It is unknown whether cosyntropin is excreted in
breast milk
and, therefore, should be used cautiously by mothers who are nursing.

What else should I know about cosyntropin-injectable?

What preparations of cosyntropin-injectable are available?

Powder (with and without preservatives) 0.25 mg; Solution: 0.25
mg/mL in 1 mL vial

How should I keep cosyntropin-injectable stored?

Cosyntropin powder should be stored at room temperature between 15 C
to 30 C (59 F to 86 F). Cosyntropin solution and suspension should be stored
under refrigeration between 2 C to 8 C (36 F to 46 F) and protected from light
and freezing. Infusions are stable for 12 hours at room temperature.


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