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tranexamic acid (Cyklokapron) Dental Drug Uses & Side Effects

What is tranexamic acid? What is tranexamic acid used for?

  • Tranexamic acid promotes the clotting of blood and thereby reduces bleeding due to tooth extractions in people with hemophilia. People with hemophilia bleed easily because they lack a specific blood protein necessary for forming blood clots.
  • Tranexamic acid is a man-made amino acid derivative that increases blood clotting by preventing the breakdown of fibrin. Fibrin is a protein and an important component of blood clots. It is broken down by another protein called plasmin. Tranexamic acid blocks the action of plasmin on fibrin and thereby prevents the breakdown of fibrin. This leads to stabilization and preservation of fibrin in blood clots. This helps reduce bleeding after a tooth extraction.
  • The FDA approved tranexamic acid injection in December, 1986.

What brand names are available for tranexamic acid?

Cyklokapron

Is tranexamic acid available as a generic drug?

Yes

Do I need a prescription for tranexamic acid?

Yes

What are the uses for tranexamic acid?

Tranexamic acid injection is used short-term (two to eight days) to
prevent bleeding following tooth extraction in people with hemophilia.

What are the side effects of tranexamic acid?

Common side effects of tranexamic acid injection include:

Other less common side effects side effects include:

What is the dosage for tranexamic acid?

  • Prior to tooth extraction, tranexamic acid should be administered at
    a dose of 10 mg per kg body weight of intravenously.
  • Thereafter, a dose of 10 mg
    per kg body weight should be given three to four times daily for 2 to 8 days
    after tooth extraction.




QUESTION

What causes tooth decay?
See Answer

Which drugs or supplements interact with tranexamic acid?

  • Concomitant use with tissue plasminogen activators (used to prevent or treat
    blood clots) can reduce the effectiveness of tranexamic acid.
  • Concomitant use with factor IX complex concentrates or anti-inhibitor
    coagulant concentrates that promote blood clots is not recommended due to the
    increased risk of blood clots.

Is tranexamic acid safe to take if I’m pregnant or breastfeeding?

  • Tranexamic acid injection has not been adequately evaluated in
    pregnant
    women.
  • Tranexamic acid is present in breast milk in trace amounts; therefore,
    caution must be exercised when it is used in
    nursing mothers.

What else should I know about tranexamic acid?

What preparations of tranexamic acid are available?

Single dose injection (vials or ampules): 100 mg/ml

How should I keep tranexamic acid stored?

Tranexamic acid injection should be stored at room temperature, 15 C
– 30 C (59 F – 86 F).

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