What is salsalate, and how does it work (mechanism of action)?
Salsalate is a
nonsteroidal anti-inflammatory drug (NSAID) that is used for treating
pain, and inflammation in the body. Salsalate is converted in the body to
salicylic acid which is its active form and is closely related to aspirin. Other
and several others. They work by reducing the levels of prostaglandins,
chemicals produced by the body that are responsible for pain, fever, and
inflammation. Salsalate blocks the enzyme that makes prostaglandins
(cyclooxygenase), resulting in lower concentrations of prostaglandins. As a
consequence, inflammation, pain and fever are reduced. Salsalate is as strong as
aspirin in reducing inflammation but has less effect on blood clotting than
What brand names are available for salsalate?
Amigesic, Salflex, Argesic-SA, Marthritic, Salsitab, Artha-G
Is salsalate available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for salsalate?
What are the side effects of salsalate?
Most patients benefit from salsalate and other NSAIDs with few
side effects. However, serious side effects can occur and generally tend to be
dose-related (are more common at higher doses). Therefore, it is advisable to
use the lowest effective dose to minimize side effects. The most common side
effects of salsalate involve the gastrointestinal system and ringing in the ears
It can cause ulcerations of the stomach and intestines, abdominal pain,
even serious gastrointestinal bleeding and liver toxicity. Sometimes, ulceration
and bleeding may occur without any
upon standing (orthostatic hypotension) may be the only signs of
bleeding. Patients who develop tinnitus may need to reduce the dose of
and lightheadedness also may occur. Fluid retention, blood clots,
What is the dosage for salsalate?
The usual dose of salsalate is 3000 mg daily given over 2-4 doses.
Salsalate should be taken with food to reduce stomach upset.
Which drugs or supplements interact with salsalate?
Salsalate, like aspirin, is converted to salicylic acid.
Therefore, adding aspirin to salsalate can cause salicylic acid toxicity.
NSAIDs may reduce the blood pressure lowering effects of blood pressure
medications. This may occur because prostaglandins play a role in the regulation
(lowering) of blood pressure.
When NSAIDs are combined with
(Rheumatrex, Trexall) or aminoglycoside antibiotics (for example, gentamicin)
the blood levels of methotrexate or aminoglycoside may increase, presumably
because the elimination of methotrexate or aminoglycosides is reduced. This may
lead to more side effects from methotrexate or aminoglycosides.
Persons who have more than 3 alcoholic beverages per day may be at increased
risk of developing stomach ulcers when taking NSAIDs.
Is salsalate safe to take if I’m pregnant or breastfeeding?
There are no adequate studies of salsalate in
Salicylic acid appears in
at levels close to maternal blood levels. This may cause adverse effects in the
infant. Nursing women should avoid nursing while taking salsalate or use
What else should I know about salsalate?
What preparations of salsalate are available?
Tablets: 500 and 750 mg
How should I keep salsalate stored?
Salsalate should be stored at room temperature, 15 C (59 F – 86