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pramoxine (Itch-X and others) – Topical: Side Effects, Dosage, and Interactions

What is pramoxine, and how does it work (mechanism of action)?

Pramoxine is a topical (used on the skin)
anesthetic (numbing agent). Topical anesthetics are chemicals that interfere
with the function of the nerves that sense pain. Pramoxine may be used in
persons who are allergic to other local anesthetics such as lidocaine, procaine,
or benzocaine.

Is it available as a generic drug?

Yes, pramoxine is available as a generic drug.

Do I need a prescription for pramoxine?

Yes, you need a prescription from your doctor or other health care professional to obtain this

What are the uses for pramoxine?

This medicine is used for the temporary relief of pain and
itching associated with:


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What are the side effects and adverse
effects of pramoxine?

In some patients, pramoxine may act as a "sensitizer,"

What is the dosage for pramoxine?

  • Apply one dose topically to the affected areas 3 to 4 times per
  • This drug is intended only for external use and should not be applied to open
    or wounds or damaged skin.
  • If the condition does not improve after 7 days of
    use, a doctor, pharmacist, or other health care professional should be consulted.

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Which drugs or supplements interact with
this medication?

There are no drug interactions listed for
this medication.

What brand names are available for pramoxine?

There are numerous brand names for pramoxine, far too many to list here. Examples include:

  • Itch-X
  • PrameGel
  • Orax
  • Sarna Sensitive

The brand Anti-Itch has been discontinued in the US.

Is this drug safe to use during pregnancy or while breastfeeding?

  • Researchers and doctors don't know if pramoxine is harmful if used
    during pregnancy.
  • Doctors and researchers don't know if pramoxine is secreted into
    human milk.
  • Consult with your doctor if you are considering using this topical
    anti-itch cream.

What else should I know about pramoxine?

This medication is available in formulations of:

  • Topical Cream: 1%
  • Topical Gel: 1%
  • Topical Lotion: 1%
  • Topical Spray: 1%

Keep this medication stored at room temperature, 15 C-30 C
(59 F-86 F).


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