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methylphenidate patch (Daytrana): Side Effects and Dosing

What is methylphenidate patch, and how does it work (mechanism of action)?

Methylphenidate is a medication used for treating
attention deficit hyperactivity disorder (ADHD). It stimulates the central
nervous system (CNS or brain) in a manner that is similar to amphetamines;
however, its actions are milder than amphetamines. Amphetamines stimulate the
brain by increasing the level of neurotransmitters, dopamine and norepinephrine,
in the brain (neurotransmitters are chemicals produced by nerves that are
released and attach to other nearby nerves as a means of communication among
nerves). The exact mechanism of action of the drug in people with ADHD is
unknown. Methylphenidate is the active ingredient in
methylphenidate (Ritalin, Concerta), and also is available as pills and liquids. The FDA approved
Methylphenidate patches in April 2006.

What brand names are available for methylphenidate patch?


Is methylphenidate patch available as a generic drug?


Do I need a prescription for methylphenidate patch?


What are the side effects of methylphenidate patch?

Side effects of methylphenidate are decreased appetite,
allergic contact dermatitis, nausea, vomiting, weight loss,
dizziness, abdominal pain, emotional instability, and

Methylphenidate may be abused and it is a Schedule II controlled medication.
Long-term abuse can cause tolerance, psychological dependence, abnormal
behavior, and psychosis. Use cautiously in people with a history of drug or
alcohol abuse.

What is the dosage for methylphenidate patch?

The recommended dose for methylphenidate patches is to apply one 10
mg patch once daily for 9 hours for week 1, then increase to 15 mg patch for
week 2, then increase to 20 mg patch for week 3, then increase to 30 mg patch
for week 4 depending on response. The patch is applied to the hip area 2 hours
before the effect is needed, and removed 9 hours after application. The dosing
is for children aged 6 to 17.

Which drugs or supplements interact with methylphenidate patch?

Methylphenidate should not be combined with
monoamine oxidase inhibitors (MAOIs) such as phenelzine (Nardil), selegiline (Zelapar,
Emsam, and Eldepryl), tranylcypromine (Parnate), procarbazine (Matulane),
rasagiline (Azilect), and isocarboxazid (Marplan) because of risks of
hypertensive crisis. Use of methylphenidate and MAO inhibitors should be
separated by at least 14 days.

Is methylphenidate patch safe to take if I’m pregnant or breastfeeding?

There are no adequate studies done on Methylphenidate to determine
safe and effective use in
pregnant women.

It is not known whether methylphenidate enters
breast milk;
therefore, it is best to be cautious before using it in nursing mothers.

What else should I know about methylphenidate patch?

What preparations of methylphenidate patch are available?

Patch: 10 mg, 15 mg, 20 mg, and 30 mg strengths, delivering
doses over 9 hours.

How should I keep methylphenidate patch stored?

Store Methylphenidate patches between temperatures of 15 C and 30 C
(59 F and 86 F). Do not store patches unpouched (outside of their container). Do
not store patches in refrigerators or freezers. Once the sealed tray or outer
pouch is opened, use contents within 2 months.


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