What what is lamivudine and zidovudine, and what is it used for?
- Combivir is used, in combination with other agents,
for the treatment of
What brand names are available for lamivudine and zidovudine?
Is lamivudine and zidovudine available as a generic drug?
Do I need a prescription for lamivudine and zidovudine?
What are the side effects of lamivudine and zidovudine?
The most serious side effects of Combivir are
- a decrease in blood cells,
- muscle pain (myopathy),
- muscle breakdown (rhabdomyolysis),
- liver enlargement,
- immune reconstitution syndrome,
- exacerbation of hepatitis B,
- fatty liver,
- hypersensitivity reactions, and
- metabolic disturbance (lactic acidosis).
Other side effects include
- abdominal pain,
- nausea and vomiting,
- weight loss,
- cough, and
Accumulation or redistribution of fat also may occur.
What is the dosage for lamivudine and zidovudine?
- For the treatment of HIV infection, the recommended oral dose for adults or children weighing 30 kg or more is one tablet twice daily.
- Combivir is administered without regard to meals since food does not affect its absorption.
Which drugs or supplements interact with lamivudine and zidovudine?
and valproic acid (Depakote) reduce the elimination of zidovudine and therefore
increase the concentration in blood of zidovudine. This can lead to increased
side effects from zidovudine.
- Lamivudine and zalcitabine (Hivid) reduce the action of one another.
Therefore Combivir should not be combined with zalcitabine.
Stavudine (Zerit) or
doxorubicin reduce the activity of zidovudine and should not be combined with
- Combining zidovudine with ganciclovir (Cytovene),
(Rebetol), or other drugs that suppress
bone marrow production of blood cells
increases the effect of zidovudine on production of blood cells.
Is lamivudine and zidovudine safe to take if I’m pregnant or breastfeeding?
- Use of Combivir
pregnancy has not been adequately
evaluated. However, use of zidovudine by HIV infected women reduces the transmission of HIV to the baby.
- Use of Combivir by
nursing mothers has not been
studied. Lamivudine and zidovudine are excreted in
breast milk. HIV infected
mothers should not breast feed because of the potential risk of transmitting HIV
to an infant that is not infected.
What else should I know about lamivudine and zidovudine?
What preparations of lamivudine and zidovudine are available?
Tablets: 150/300 mg (lamivudine/zidovudine)
How should I keep lamivudine and zidovudine stored?
The tablets should be stored at 2 C to 30 C (36 F to 86 F).