What is Advair Diskus, Advair HFA (fluticasone propionate and salmeterol oral inhaler)?
What brand names are available for fluticasone propionate and salmeterol oral inhaler?
Advair Diskus and Advair HFA are the brand names available for
fluticasone propionate and salmeterol oral inhaler in the US.
Is Advair Diskus, Advair HFA (fluticasone propionate and salmeterol oral inhaler) available as a generic drug?
Do I need a prescription for Advair Diskus, Advair HFA (fluticasone propionate and salmeterol oral inhaler)?
What are the uses for Advair Diskus, Advair HFA (fluticasone propionate and salmeterol oral inhaler)?
- Advair Diskus is used for the treatment of asthma or chronic obstructive pulmonary disease (COPD) associated with chronic bronchitis. Its action starts within 30 to 60 minutes and can last more than 12 hours.
- Advair Diskus is generally not needed in patients whose asthma can be controlled easily with infrequent administration of short acting inhalers.
- Advair HFA is used for treating asthma in individuals 12 years old or older.
- Advair Diskus or HFA should not be used to treat acute episodes of asthma or COPD.
What are the side effects of Advair Diskus, Advair HFA (fluticasone propionate and salmeterol oral inhaler)?
- Use of long acting agents like salmeterol, an active ingredient in Advair, may increase the risk of asthma-related death. Therefore, Advair should only be used in patients whose asthma is uncontrolled by other agents, and who are using long-term asthma-controlling medications such as an inhaled corticosteroid.
- Upper respiratory tract infections occur in 20%
to 25% of patients using Advair.
- Headaches occur in about 1 in 8 patients who use it.
- Other common adverse events include:
Use of long acting agents like
salmeterol, an active ingredient in Advair, may increase the risk of asthma-related death. Therefore, Advair should only be used in patients whose asthma is uncontrolled by other agents, and who are using long-term asthma-controlling medications such as an inhaled corticosteroid.
Serious adverse events of Advair include:
Serious allergic reactions include:
- Adrenal suppression
- Growth suppression
- High blood pressure
- Low blood pressure
- Worsening of asthma
- High blood glucose
- Low potassium
- Cardiac arrest
What is the dosage for Advair Diskus, Advair HFA (fluticasone propionate and salmeterol oral inhaler)?
- The recommended Advair Diskus regimen for asthma in individuals 12 years and older is one inhalation twice daily (morning and evening) approximately 12 hours apart.
- The lowest effective strength should be used and the maximum dose is 500/50 mcg twice daily.
- For children 4 to 11 years old the recommended treatment is one inhalation of 100/50 mcg twice daily.
- The recommended regimen of Advair Diskus for
COPD is one inhalation of 250/50 mcg twice daily. Higher doses are not more effective.
- The recommended dose for Advair HFA is 2 inhalations twice daily. The lowest effective dose should be used.
The Diskus device is held in one hand with the thumb of the other hand placed on the thumb-grip. The thumb is then pulled away as far as the device allows until the mouthpiece seems to click into position. With the Diskus then held horizontally and with the mouthpiece towards the patient, the lever is then slid away as far as it can go until it clicks. The patient breathes out as far as comfortable, then placing his mouth to the mouthpiece, breathes in quickly and deeply and holds his breath for about ten seconds. The patient then washes his or her mouth without swallowing after inhalation.
Which drugs or supplements interact with Advair Diskus, Advair HFA (fluticasone propionate and salmeterol oral inhaler)?
Monoamine oxidase inhibitors
or MOAIs (for example, tranylcypromine) and
Elavil]) may increase the effect of salmeterol on the heart and
blood pressure. Since Advair contains salmeterol, it should not be used with or within two weeks of discontinuing monoamine oxidase inhibitors or tricyclic antidepressants.
nelfinavir (Viracept), and
telithromycin (Ketek) may increase levels of fluticasone in the body by reducing the breakdown of fluticasone by
liver enzymes. This may increase side effects of Advair.
- Beta blockers (for example, propranolol) block the effect of salmeterol and may also produce severe bronchospasm in patients with asthma. Therefore, patients with asthma should not be treated with beta-blockers unless it is absolutely necessary. Beta-blockers that have less effect on the heart should be used if a beta-blocker must be combined with salmeterol.
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Is Advair Diskus, Advair HFA (fluticasone propionate and salmeterol oral inhaler) safe to use during pregnancy or while breastfeeding?
- Adequate studies of fluticasone or inhaled salmeterol during
pregnancy have not been done. Fluticasone use
during pregnancy should be avoided unless the potential benefit justifies the potential but unknown risk to the fetus. In some, but not all pregnant animal models, exposure to very high doses of oral salmeterol has led to offspring with
birth defects. The concentrations of salmeterol in the blood after these very high doses, however, were much higher than the concentrations observed after inhalation by patients. Nevertheless, salmeterol inhalation should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
- It is not known if fluticasone propionate is secreted in
breast milk. Other medications in the same class as fluticasone propionate are secreted into breast milk, but it is not known whether the small amounts that may appear in the milk have effects on
nursing infants. In rats, salmeterol is excreted in milk. Therefore, caution should be exercised when salmeterol is administered to nursing women.
What else should I know about Advair Diskus, Advair HFA (fluticasone propionate and salmeterol oral inhaler)?
What preparations of Advair Diskus, Advair HFA (fluticasone propionate and salmeterol oral inhaler) are available?
- Advair Diskus is an oral inhalation powder available in three different forms containing the same amount of salmeterol, 50 mcg, but differing in the amount of fluticasone propionate.
- 100/50 provides 100 mcg of fluticasone propionate, 250/50 provides 250 mcg of fluticasone propionate, and 500/50 contains 500 mcg of fluticasone propionate per inspiration.
- Advair HFA is an oral
aerosol containing 21 mcg of salmeterol combined with 45, 115, or 230 mcg fluticasone.
How should I keep Advair Diskus, Advair HFA (fluticasone propionate and salmeterol oral inhaler) stored?
- Advair should be stored at room temperature, 68 F to 77 F (20
C to 25 C).
- It should be kept away from heat or flames and should not be punctured.
- It should not be frozen or placed in direct sunlight.
How does Advair Diskus, Advair HFA (fluticasone propionate and salmeterol oral inhaler) work?
- In patients with
asthma, the smaller airways (bronchioles) through which air moves in and out of the
lungs can be narrowed by accumulation of mucus, spasm of the muscles that surround these airways, or swelling of the lining of the airways due to inflammation.
Airway narrowing leads to symptoms of
shortness of breath,
congestion. Medications used in treating
asthma include those that open airways, called bronchodilators, and those that reduce inflammation.
- Advair contains a combination of
salmeterol, a bronchodilator of the beta-2 agonist type, and
fluticasone propionate, an anti-inflammatory corticosteroid. Beta-2 agonists are medications that attach to beta-2 receptors on the smooth muscle cells that surround the airways, causing the muscle cells to relax and open the airways. Fluticasone propionate is a synthetic (man-made) corticosteroid of the glucocorticoid family which is related to the natural hormone, cortisol or hydrocortisone, produced by the adrenal glands. Glucocorticoid steroids have potent anti-inflammatory actions. In asthmatic patients, the suppression of inflammation within the airways reduces the swelling caused by inflammation that narrows the airways. At the same time, production of mucus is reduced. When used in lower doses, very little inhaled fluticasone propionate is absorbed into the body and side effects are infrequent. When higher doses are used, fluticasone is absorbed and may cause side effects elsewhere in the body.
When was Advair Diskus, Advair HFA (fluticasone propionate and salmeterol oral inhaler) approved by the FDA?
- The FDA approved Advair Diskus in August, 2000 and Advair HFA in June 2006.