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Homebreast cancerDiprolene (Betamethasone Dipropionate) vs. Topicort (desoximetasone)

Diprolene (Betamethasone Dipropionate) vs. Topicort (desoximetasone)

Diprolene (betamethasone dipropionate) vs. Topicort (desoximetasone): What’s the difference?

What is Betamethasone dipropionate? What is desoximetasone?

Betamethasone is a corticosteroid topical medication used for the relief of itching and inflammation associated with a wide variety of skin conditions in patients 13 years of age or older. Examples include allergic dermatitis, atopic dermatitis, contact dermatitis, and plaque psoriasis.

Desoximetasone is a topical (for the skin) corticosteroid used to treat adults with moderate to severe plaque psoriasis and to treat other skin conditions that are responsive to corticosteroids. The naturally-occurring corticosteroid is cortisol or hydrocortisone produced by the adrenal gland. Corticosteroids have potent anti-inflammatory actions and also suppress the immune response.


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What are the side effects of betamethasone and desoximetasone?


The most common side effects of betamethasone are:

  • burning at the area of application,
  • itching,
  • irritation, and
  • dryness.


Common side effects of Topicort include:

  • Burning
  • Itching
  • Irritation
  • Dryness

Other side effects include:

Other less common side effects include:

Possible serious side effects include:

  • Maceration of the skin
  • Secondary infection
  • Skin atrophy

Prolonged use (greater than two weeks) of high doses of Topicort can depress the ability of the body's adrenal glands to produce corticosteroids. Abruptly stopping Topicort in these individuals can cause symptoms of corticosteroid insufficiency, along with:

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What is the dosage of betamethasone vs. desoximetasone?


  • A thin strip of betamethasone cream or ointment is applied gently to the affected area once or twice daily.
  • A few drops of the lotion is applied to the affected area once or twice daily.
  • The lotion should be massaged gently until it disappears.

Large doses and prolonged use of betamethasone may cause large amounts to be absorbed into the body and suppress production of cortisol by the adrenal glands.

Therefore, the lotion should not be used for longer than two weeks, and not more than 50 ml should be used per week. The augmented cream or ointment should be limited to 45 grams per week. Betamethasone should not be used with occlusive dressings because occlusive dressings increase absorption into the body.


  • A thin film of Topicort should be applied to the affected areas twice daily.
  • Using Topicort beyond 4 weeks is not advisable.

What drugs interact with betamethasone and desoximetasone?


Combining topical steroids with topical anthralin may increase psoriasis symptoms. Therefore, topical steroids should be discontinued 1 week before starting anthralins.


There are no drug interactions listed for this product.

Are betamethasone and desoximetasone safe to use while pregnant or breastfeeding?


Use of betamethasone in pregnant women has not been studied. When corticosteroids are given systemically (orally, intramuscularly or intravenously) to pregnant animals fetal abnormalities occur.

It is not known if betamethasone is secreted in breast milk. Corticosteroids absorbed into the body may appear in breast milk and may cause harmful effects in breast fed infants.


Topicort has not been adequately evaluated in pregnant women. Pregnant patients should not use corticosteroids extensively, in large amounts, or for prolonged periods of time.

It is not known if Topicort is secreted in breast milk.


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