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dapagliflozin (Farxiga): Click for Side Effects and Dosage

What is dapagliflozin, and how does it work (mechanism of action)?

Dapagliflozin (Farxiga) is an oral medication used
to improve glycemia (blood glucose) control in patients with
type 2 diabetes.
Dapagliflozin is a sodium-glucose cotransporter (SGLT2) inhibitor. It is similar
to canagliflozin (Invokana) and empagliflozin (Jardiance). SGLT2 is found in the
kidney tubules and is responsible for reabsorbing the majority of glucose
filtered out of the blood by the kidneys. By inhibiting SGLT2 dapagliflozin
reduces the reabsorption of filtered glucose and consequently increases
excretion of glucose in the urine. Dapagliflozin is not recommended for use in
patients with moderate to severe kidney disease. Dapagliflozin was approved by the US FDA in January 2014.

What brand names are available for dapagliflozin?


Is dapagliflozin available as a generic drug?


Do I need a prescription for dapagliflozin?


What are the side effects of dapagliflozin?

The most common side effects associated with dapagliflozin

Other reported side effects include:

What is the dosage for dapagliflozin?

  • The recommended starting dose of dapagliflozin is 5 mg by mouth once
    daily in the morning.
  • Dapagliflozin may be taken with or without food.
  • The dose
    may be increased to 10 mg once daily in patients who require additional glycemic
    control. Kidney function must be assessed before starting treatment.
  • Dapagliflozin should not be used in patient whose estimated glomerular
    filtration rate (eGFR) is <60 ml/min/1.73m2.

Which drugs or supplements interact with dapagliflozin?

: No significant drug interactions have been reported with
dapagliflozin use.

Is dapagliflozin safe to take if I’m pregnant or breastfeeding?

It is not known if dapagliflozin is excreted in human
milk. However, dapagliflozin is secreted in the milk of lactating rats, and
exposure showed risk to the developing kidneys in the rat fetus. Currently, the
manufacturer does not recommend use of this medication while nursing.

What else should I know about dapagliflozin?

What preparations of dapagliflozin are available?

Oral tablets: 5 and 10 mg

How should I keep dapagliflozin stored?

Tablets may be stored at room temperature, between 20 C to 25 C (68
F to 77 F).


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