choline magnesium salicylate, Trilisate: Drug Facts, Side Effects and Dosing

What is choline magnesium salicylate, and how does it work (mechanism of action)?

Choline magnesium salicylate (or trisalicylate) is
a type of

nonsteroidal anti-inflammatory drug (NSAID), referred to as a salicylate,
which is effective in treating
pain, and inflammation in the body. Other drugs within the same class are
(Dolobid) and
salsalate (Disalcid). They work by reducing the levels of prostaglandins,
chemicals that are responsible for pain, fever, and inflammation. The
salicylates block the enzyme that makes prostaglandins (cyclooxygenase),
resulting in lower concentrations of prostaglandins. As a consequence,
inflammation, pain and fever are reduced.

What brand names are available for choline magnesium salicylate?

Trilisate (Please Note: This brand name drug is no longer
available in the US)

Is choline magnesium salicylate available as a generic drug?


Do I need a prescription for choline magnesium salicylate?


What are the side effects of choline magnesium salicylate?

Common side effects of choline magnesium salicylate are
heartburn, stomach ulcers,
nausea, or
Patients should tell their doctor immediately if any of these unusual but
potentially serious side effects occur: severe

abdominal pain,
easy bruising
or bleeding, fast heartbeat, persistent
nausea or vomiting, unusual tiredness,
change in the amount or color of urine, yellowing of the eyes or skin, unusual
bleeding, and hearing loss.

What is the dosage for choline magnesium salicylate?

For rheumatoid arthritis, osteoarthritis, other severe arthritis, and
acute painful joints, the recommended starting dosage is 1500 mg given twice a
day. The recommended dose range is 1000 to 3000 mg given every 8 to 12 hours.

For mild to moderate pain or fever, the usual dosage is 1000 mg to 1500 mg every
12 hours.

It should be taken with food to prevent an upset stomach. This drug
should not be used in children or teens with
chickenpox or
flu symptoms.

Which drugs or supplements interact with choline magnesium salicylate?

: Choline magnesium salicylate, as other salicylates, should
not be given within six weeks of
influenza virus
vaccine as this can increase risk of
Reye's syndrome
(a serious, often fatal disease that causes numerous detrimental effects to many
organs, especially the brain and liver) due to unknown mechanisms.

When choline magnesium salicylate is used in combination with
methotrexate (Rheumatrex,
Trexall), an

antimetabolite, the blood levels of methotrexate may increase, presumably
because the elimination of methotrexate from the body is reduced. This may lead
to more methotrexate-related side effects.

Concurrent use of choline magnesium salicylate and
(Coumadin), a blood thinner, may cause excessive bleeding as choline magnesium
salicylate enhances the effect of warfarin. It is therefore important to reduce
the dosage of warfarin.

NSAIDs may reduce the blood pressure-lowering effects of drugs that are given
to reduce blood pressure. This may occur because prostaglandins play a role in
the regulation of blood pressure.

Persons who have more than three alcoholic beverages per day may be at
increased risk of developing

stomach ulcers when taking choline magnesium salicylate or other NSAIDs.


The term arthritis refers to stiffness in the joints.
See Answer

Is choline magnesium salicylate safe to take if I’m pregnant or breastfeeding?

Choline magnesium salicylate is excreted in
breast milk;
therefore, caution should be exercised when administering it to nursing women.

What else should I know about choline magnesium salicylate?

What preparations of choline magnesium salicylate are available?

Tablets: 500, 750, and 1000 mg. Liquid: 500 mg/5 ml.

How should I keep choline magnesium salicylate stored?

Choline magnesium salicylate should be stored at controlled room
temperature 15 C to 30 C (59 F to 86 F) in a sealed container protected from
light and moisture.

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