What is glyburide, and how does it work (mechanism of action)? Glyburide is an oral, glucose-lowering drug in a class of diabetic drugs called sulfonylureas that is used for treating diabetes. Other sulfonylureas include glipizide (Glucotrol), glimepiride (Amaryl), tolbutamide (Orinase), tolazamide, and chlorpropamide (Diabinese). Insulin is a hormone that is made in the pancreas. When …
Read More »
What is glucagon? Glucagon is a hormone produced by the pancreas that, along with insulin, controls the level of glucose in the blood. Glucagon has the opposite effect of insulin. It increases the glucose levels in blood. Glucagon, the drug, is a synthetic (man-made) version of human glucagon and is manufactured by genetic engineering using the bacteria Escherichia coli. Is …
Read More »
What is repaglinide, and how does it work (mechanism of action)? Repaglinide is an oral medication for lowering blood sugar (glucose) in individuals with type 2 diabetes. It is in a class of drugs for treating diabetes type 2 called meglitinides that are chemically unlike other anti-diabetic medications. Nateglinide (Starlix), is another currently available meglitinide. Approximately 90% of patients with …
Read More »
What is linagliptin? What are the uses for linagliptin? Tradjenta is combined with diet and exercise to improve blood glucose levels in patients with type 2 diabetes. It should not be used for treating type 1 diabetes or diabetic ketoacidosis because it would not be effective in these conditions. Tradjenta has not been studied in patients with a history of …
Read More »
What is canagliflozin? What is canagliflozin used for? Canagliflozin is an oral drug that reduces blood sugar (glucose) levels in patients with type 2 diabetes. It is a new type of diabetes medication in a class of medications called sodium-glucose co-transporter 2 (SGLT2) inhibitors. Under normal conditions, glucose is filtered out of the blood and into the kidney tubules as …
Read More »
What is glipizide, and how does it work (mechanism of action)? Glipizide is an oral drug that is used for treating patients with type 2 diabetes. It belongs to the sulfonylurea class of drugs which also includes glimepiride (Amaryl), glyburide (Diabeta, Glynase), tolbutamide and tolazamide. Insulin is a hormone that is made in the pancreas that when released into the …
Read More »
What is metformin and sitagliptin? What is Janumet used for? Janumet is a combination of two drugs, metformin and sitagliptin, that are used for reducing blood glucose (sugar) levels in individuals with type 2 diabetes. The FDA approved Janumet in March 2007. Insulin is a hormone produced by the pancreas. It limits blood glucose levels by reducing the amount of …
Read More »
What are SGLT2 inhibitors? SGLT2 (sodium-glucose co-transporter 2) inhibitors are prescription oral medications used to treat type 2 diabetes. What generic and brand names of SGLT2 inhibitors are available in the US? Brand and generic names of SGLT2 inhibitors and combination products that contain SGLT2 inhibitors include: canagliflozin (Invokana) canagliflozin/metformin (Invokamet) canagliflozin/metformin extended release (Invokamet XR) dapagliflozin (Farxiga) dapagliflozin/metformin extended …
Read More »
What is insulin glargine, and how does it work (mechanism of action)? Insulin glargine is a bioengineered (man-made) injectable form of long-acting insulin that is used to regulate sugar (glucose) levels in type 1 and type 2 diabetes. Individuals with type 1 diabetes do not produce insulin on their own; and individuals with type 2 diabetes do not produce enough …
Read More »
What is sitagliptin? What is sitagliptin used for? Sitagliptin is an oral drug that reduces blood sugar (glucose) levels in patients with type 2 diabetes. Sitagliptin is indicated as an adjunct to diet and exercise. Sitagliptin should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis, as it would not be effective in …
Read More »