atenolol/chlorthalidone, Tenoretic: Drug Facts and Side Effects

What is atenolol and chlorthalidone, and how does it work (mechanism of action)?

Atenolol/chlorthalidone is a combination of atenolol (Tenormin) and chlorthalidone (Hygroton) used for the treatment of high blood pressure. Atenolol is a beta-adrenergic blocking agent that blocks the effects of adrenergic drugs, for example, adrenaline or epinephrine, on nerves of the sympathetic nervous system. Atenolol reduces the heart rate and is useful in treating
abnormally rapid heart rhythms. Atenolol also reduces the force of contraction of heart muscle and lowers blood pressure. Chlorthalidone is a diuretic (water pill). It works by reducing the kidneys’ ability to hold on to salt and water and increasing the kidneys’ production of urine (diuresis). It is used to eliminate excess salt and water from the body and to treat high blood pressure. The FDA approved atenolol/chlorthalidone in June 1984.

What brand names are available for atenolol and chlorthalidone?


Is atenolol and chlorthalidone available as a generic drug?


Do I need a prescription for atenolol and chlorthalidone?


What are the side effects of atenolol and chlorthalidone?

Side effects of Atenolol/chlorthalidone are similar to side effects form the individual components and are:

What is the dosage for atenolol and chlorthalidone?

The recommended dose of atenolol/chlorthalidone is one tablet once daily starting with 50 mg/25 mg then increasing to 100 mg/25 mg if blood pressure control is not adequate.

Which drugs or supplements interact with atenolol and chlorthalidone?

  • Chlorthalidone can lower blood potassium and magnesium levels because both potassium and magnesium are lost in the urine.
  • Chlorthalidone reduces the kidney’s ability to eliminate
    lithium (Lithobid) in the urine. As a result, patients taking chlorthalidone at the same time as drugs containing lithium may develop high levels of lithium and/or lithium toxicity.
  • Atenolol can mask the early warning symptoms of low blood sugar (hypoglycemia), and should be used with caution in patients receiving treatment for diabetes. Combining atenolol with other drugs that reduce blood pressure or slow heart rate may lead to excessive blood pressure reduction or low heart rate.


Salt and sodium are the same.
See Answer

Is atenolol and chlorthalidone safe to take if I’m pregnant or breastfeeding?

Atenolol is excreted in breast milk and may adversely affect the infant. Atenolol/chlorthalidone should be avoided while

What else should I know about atenolol and chlorthalidone?

What preparations of atenolol and chlorthalidone are available?

Tablets: atenolol 50mg and chlorthalidone
25mg; atenolol 100mg and chlorthalidone 25mg.

How should I keep atenolol and chlorthalidone stored?

Tablets should be stored at room temperature,
15C and 30 C (59 F and 86 F).

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