Urodynamic Testing: Facts on Results and Side Effects

What is the urinary tract?

The urinary tract is the body's drainage system for removing wastes and extra water. The urinary tract includes two kidneys, two ureters, a bladder, and a urethra. Blood flows through the kidneys, and the kidneys filter out wastes and extra water, making urine. The urine travels down two narrow tubes called the ureters. The urine is then stored in a muscular, balloonlike organ called the bladder. The bladder swells into a round shape when it is full and gets smaller as it empties. When the bladder empties, urine flows out of the body through the urethra.

What is the lower urinary tract and how does it work?

The lower urinary tract includes the bladder and urethra. The bladder sits in the pelvis and is attached to other organs, muscles, and the pelvic bones, which hold it in place. The urethra is a tube at the bottom of the bladder that carries urine from the bladder to the outside of the body.

The lower urinary tract works by coordinating the muscles of the bladder wall with the sphincters, which are circular muscles that surround the area of the bladder that opens into the urethra. The muscles of the bladder wall relax as the bladder fills with urine. If the urinary tract is healthy, the bladder can hold up to 2 cups, or 16 ounces, of urine comfortably for 2 to 5 hours. The sphincters close tightly like rubber bands around the bladder to help keep urine from leaking. As the bladder fills, the need to urinate becomes stronger and stronger, until the bladder reaches its limit. Urination is the process of emptying the bladder. To urinate, the brain signals the bladder muscles to tighten, squeezing urine out of the bladder. At the same time, the brain signals the sphincters to relax. As the sphincters relax, urine exits the bladder through the urethra. When all the signals occur in the correct order, normal urination occurs.

Picture of the front view of the urinary tract; SOURCE: NIH

What is urodynamic testing?

Urodynamic testing is any procedure that looks at how well the bladder, sphincters, and urethra are storing and releasing urine. Most urodynamic tests focus on the bladder's ability to hold urine and empty steadily and completely. Urodynamic tests can also show whether the bladder is having involuntary contractions that cause urine leakage. A health care provider may recommend urodynamic tests if symptoms suggest problems with the lower urinary tract. Lower urinary tract symptoms (LUTS) include

urine leakage
frequent urination
painful urination
sudden, strong urges to urinate
problems starting a urine stream
problems emptying the bladder completely
recurrent urinary tract infections

Urodynamic tests range from simple observation to precise measurements using sophisticated instruments. For simple observation, a health care provider may record the length of time it takes a person to produce a urinary stream, note the volume of urine produced, and record the ability or inability to stop the urine flow in midstream. For precise measurements, imaging equipment takes pictures of the bladder filling and emptying, pressure monitors record the pressures inside the bladder, and sensors record muscle and nerve activity. The health care provider will decide the type of urodynamic test based on the person's health information, physical exam, and LUTS. The urodynamic test results help diagnose the cause and nature of a lower urinary tract problem.

Most urodynamic tests do not involve special preparations, though some tests may require a person to make a change in fluid intake or to stop taking certain medications. Depending on the test, a person may be instructed to arrive for testing with a full bladder.

What are the urodynamic tests?

Urodynamic tests include

uroflowmetry
postvoid residual measurement
cystometric test
leak point pressure measurement
pressure flow study
electromyography
video urodynamic tests

Uroflowmetry

Uroflowmetry is the measurement of urine speed and volume. Special equipment automatically measures the amount of urine and the flow rate — how fast the urine comes out. Uroflowmetry equipment includes a device for catching and measuring urine and a computer to record the data. During a uroflowmetry test, the person urinates privately into a special toilet or funnel that has a container for collecting the urine and a scale. The equipment creates a graph that shows changes in flow rate from second to second so the health care provider can see when the flow rate is the highest and how many seconds it takes to get there. Results of this test will be abnormal if the bladder muscles are weak or urine flow is blocked. Another approach to measuring flow rate is to record the time it takes to urinate into a special container that accurately measures the volume of urine. Uroflowmetry measurements are performed in a health care provider's office; no anesthesia is needed.

Picture of uroflowmetry equipment; SOURCE: NIH

Postvoid Residual Measurement

This urodynamic test measures the amount of urine left in the bladder after urination. The remaining urine is called the postvoid residual. Postvoid residual can be measured with ultrasound equipment that uses harmless sound waves to create a picture of the bladder. Bladder ultrasounds are performed in a health care provider's office, radiology center, or hospital by a specially trained technician and interpreted by a doctor, usually a radiologist. Anesthesia is not needed. Postvoid residual can also be measured using a catheter — a thin flexible tube. A health care provider inserts the catheter through the urethra up into the bladder to remove and measure the amount of remaining urine. A postvoid residual of 100 milliliters or more is a sign that the bladder is not emptying completely. Catheter measurements are performed in a health care provider's office, clinic, or hospital with local anesthesia.

Cystometric Test

A cystometric test measures how much urine the bladder can hold, how much pressure builds up inside the bladder as it stores urine, and how full it is when the urge to urinate begins. A catheter is used to empty the bladder completely. Then a special, smaller catheter is placed in the bladder. This catheter has a pressure-measuring device called a manometer. Another catheter may be placed in the rectum to record pressure there.

Once the bladder is emptied completely, the bladder is filled slowly with warm water. During this time, the person is asked to describe how the bladder feels and indicate when the need to urinate arises. When the urge to urinate occurs, the volume of water and the bladder pressure are recorded. The person may be asked to cough or strain during this procedure to see if the bladder pressure changes. A cystometric test can also identify involuntary bladder contractions. Cystometric tests are performed in a health care provider's office, clinic, or hospital with local anesthesia.

Picture of a cystometric test; SOURCE: NIH

Leak Point Pressure Measurement

This urodynamic test measures pressure at the point of leakage during a cystometric test. While the bladder is being filled for the cystometric test, it may suddenly contract and squeeze some water out without warning. The manometer measures the pressure inside the bladder when this leakage occurs. This reading may provide information about the kind of bladder problem that exists. The person may be asked to apply abdominal pressure to the bladder by coughing, shifting position, or trying to exhale while holding the nose and mouth. These actions help the health care provider evaluate the sphincters.

Pressure Flow Study

A pressure flow study measures the bladder pressure required to urinate and the flow rate a given pressure generates. After the cystometric test, the person empties the bladder, during which time a manometer is used to measure bladder pressure and flow rate. This pressure flow study helps identify bladder outlet blockage that men may experience with prostate enlargement. Bladder outlet blockage is less common in women but can occur with a cystocele or, rarely, after a surgical procedure for urinary incontinence. Pressure flow studies are performed in a health care provider's office, clinic, or hospital with local anesthesia.

Electromyography

Electromyography uses special sensors to measure the electrical activity of the muscles and nerves in and around the bladder and the sphincters. If the health care provider thinks the urinary problem is related to nerve or muscle damage, the person may be given an electromyography. The sensors are placed on the skin near the urethra and rectum or on a urethral or rectal catheter. Muscle and nerve activity is recorded on a machine. The patterns of the nerve impulses show whether the messages sent to the bladder and sphincters are coordinated correctly. Electromyography is performed by a specially trained technician in a health care provider's office, outpatient clinic, or hospital. Anesthesia is not needed if sensors are placed on the skin. Local anesthesia is needed if sensors are placed on a urethral or rectal catheter.

Video Urodynamic Tests

Video urodynamic tests take pictures and videos of the bladder during filling and emptying. The imaging equipment may use x-rays or ultrasound. If x-ray equipment is used, the bladder will be filled with a special fluid, called contrast medium, that shows up on x rays. X rays are performed by an x-ray technician in a health care provider's office, outpatient facility, or hospital; anesthesia is not needed. If ultrasound equipment is used, the bladder is filled with warm water and harmless sound waves are used to create a picture of the bladder. The pictures and videos show the size and shape of the bladder and help the health care provider understand the problem. Bladder ultrasounds are performed in a health care provider's office, radiology center, or hospital by a specially trained technician and interpreted by a doctor, usually a radiologist. Although anesthesia is not needed for the ultrasound, local anesthesia is needed to insert the catheter to fill the bladder.

What happens after urodynamic tests?

After having urodynamic tests, a person may feel mild discomfort for a few hours when urinating. Drinking an 8-ounce glass of water every half-hour for 2 hours may help to reduce the discomfort. The health care provider may recommend taking a warm bath or holding a warm, damp washcloth over the urethral opening to relieve the discomfort.

An antibiotic may be prescribed for 1 or 2 days to prevent infection, but not always. People with signs of infection — including pain, chills, or fever — should call their health care provider immediately.

How soon will test results be available?

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Results for simple tests such as cystometry and uroflowmetry are often available immediately after the test. Results of other tests such as electromyography and video urodynamic tests may take a few days to come back. A health care provider will talk with the patient about the results and possible treatments.

Points to Remember

The urinary tract is the body's drainage system for removing wastes and extra water.
The lower urinary tract includes the bladder and urethra.
Urodynamic testing is any procedure that looks at how well the bladder, sphincters, and urethra are storing and releasing urine.
Most urodynamic tests focus on the bladder's ability to hold urine and empty steadily and completely.
Urodynamic tests include uroflowmetry, postvoid residual measurement, cystometric test, leak point pressure measurement, pressure flow study, electromyography, and video urodynamic tests.
Most urodynamic tests do not involve special preparations. Depending on the test, a person may be instructed to arrive for testing with a full bladder.
After having urodynamic tests, a person may feel mild discomfort for a few hours when urinating.
Results for simple tests are often available immediately after the test, while other test results may take a few days to come back.

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Hope through Research

In recent years, researchers have learned much about the causes and treatment of lower urinary tract problems. Researchers are looking into ways to more accurately assess LUTS and diagnose lower urinary tract problems. Research focuses on designing and developing more accurate and reliable diagnostic tests and tools.

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sponsors studies of diagnostic urodynamic methods and devices. The NIDDK also sponsors programs aimed at understanding, diagnosing, and treating lower urinary tract problems. NIDDK-funded studies have shown associations between LUTS and nonurologic diseases and conditions. These findings have important diagnostic and management implications. Continued improvement in urodynamic testing will help support advancements in understanding these associations.

Participants in clinical trials can play a more active role in their own health care, gain access to new research treatments before they are widely available, and help others by contributing to medical research. For information about current studies, visit www.ClinicalTrials.gov.

For More Information

American Urological Association Foundation
1000 Corporate Boulevard
Linthicum, MD 21090
Phone: 1-800-828-7866 or 410-689-3700
Fax: 410-689-3998
Email: [email protected]
Internet: www.UrologyHealth.org

Interstitial Cystitis Association
100 Park Avenue, Suite 108-A
Rockville, MD 20850
Phone: 1-800-HELP-ICA (1-800-435-7422) or 301-610-5300
Email: [email protected]
Internet: www.ichelp.org