Thymoma Prognosis, Symptoms, Diagnosis & Staging

Thymoma facts

A thymoma is a type of tumor or growth in the thymus gland. Thymic tumors are tumors of the thymus gland.
Physicians describe thymomas in terms of their degree of spread. Most thymomas have the potential to behave like a cancer and spread beyond the thymus, but many appear to behave in a benign fashion and are noninvasive. Less commonly, it appears to have spread beyond the thymus. People sometimes refer to such an invasive thymoma as malignant thymoma. When the pattern of spread is clearly typical for cancer, thymic carcinoma (cancer) is the term most often used.
The thymus gland is present in the front of the space between the upper lungs called the anterior mediastinum and behind the upper sternum. The thymus gland is larger during puberty but then normally becomes smaller in adulthood.
Thymomas most frequently appear in people in the fourth and fifth decades of life.
There are no known risk factors that predispose a person to developing a thymoma.
Up to half of thymomas are asymptomatic, meaning they do not produce any symptoms or signs and physicians diagnose them when they perform an imaging study of the chest for another reason.
Chest pain, shortness of breath, and cough are common symptoms that may be present when symptoms do occur.
Many patients with thymoma will have a so-called paraneoplastic syndrome. A paraneoplastic syndrome occurs preceding or concurrent with the discovery of the thymoma. These conditions accompany the cancer's development but are not a direct result of the disease as a lump or pain might be. They seem to be an indirect result of the cancer and may or may not improve with the treatment of the underlying disease. The most commonly associated condition with thymoma is myasthenia gravis, a disease of muscle. Twenty percent of patients with myasthenia gravis have a thymoma.
Thymomas are slow-growing tumors, and the prognosis is excellent when discovered in their early stages.
Surgical removal (surgical resection) is the mainstay of treatment. Chemotherapy, targeted therapy, and radiation therapy may be used in cases in which surgical treatment is not effective in removing the entire tumor or in particularly aggressive cases.

Thymoma Symptoms & Signs

Up to half of thymomas do not produce any symptoms or signs, and they are first diagnosed when physicians perform an imaging study of the chest for another reason. When symptoms do occur, these can include

chest pain,
cough, and
shortness of breath.

What is thymoma?

A thymoma is a rare type of tumor of the thymus gland. The thymus is a gland located in the anterior mediastinum (the area between the two lungs and the sternum in the chest) that plays a critical role in the development of immune cells (lymphocytes) during childhood. The thymus gland enlarges during childhood, peaks in size at puberty (about 40 grams), and then begins to shrink.

Normally, a combination of lymphoid cells (immune cells or lymphocytes) and lining cells (epithelial cells) makes up the thymus. Thymoma is a type of tumor that originates from the epithelial or lining cells of the thymus. The term thymic neoplasms refers to tumors of the thymus, which consist of thymomas and thymic carcinomas. The term thymoma refers to tumors of the thymus that grow slowly and usually do not spread beyond the thymus. Thymic carcinomas are tumors of the thymus that grow aggressively and may metastasize to distant organs. Less than one person per 1.5 million people will develop a thymoma. This means about 400 people per year in the U.S. develop thymoma. Thymic carcinomas are very rare and make up only 0.06% of all thymic tumors.

What causes thymoma, and what are risk factors for thymoma?

The exact cause of thymomas is unknown. Thymomas are equally common in men and in women and are most frequently seen in the fourth and fifth decades of life. There are no known risk factors that predispose a person to developing thymoma.

What are signs and symptoms of thymoma?

Up to 50% of thymomas are asymptomatic, meaning they do not produce any symptoms or signs. Physicians may diagnose a thymoma when they perform an imaging study for another reason. In other cases, the tumor may cause symptoms related to the size of the tumor and the pressure it exerts on adjacent organs.

Chest pain,
shortness of breath, and
cough are common symptoms when symptoms do occur.

The following symptoms and signs are less common but may occur:

Some cases may spread to the lining of the lungs or heart or even to tissues outside the chest. Less than 7% of cases spread outside the chest cavity. Thymic carcinomas are more aggressive types of tumors than thymomas and are more likely to spread both locally and distantly (metastasize) and to cause symptoms.

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What other types of medical conditions are associated with thymoma?

A number of health conditions have been associated with thymoma. Medical conditions associated with cancers are paraneoplastic syndromes, and up to 50%-60% of patients with thymoma will have one of these related health conditions. The most commonly associated condition with thymoma is myasthenia gravis, an autoimmune disease of the nerve-muscle junction that can manifest as weakness, fatigue, double vision, ptosis (drooping eyelids), and problems with swallowing.

Other associated conditions include other autoimmune diseases including pure red cell aplasia (underproduction of red blood cells in the bone marrow).

What types of specialists treat thymomas?

Surgeons, including thoracic (chest) surgeons and surgical oncologists, typically treat thymoma. Medical oncologists and radiation oncologists may be involved in the treatment team if other treatments indicate an aggressive thymoma or thymic carcinoma.

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How do health care professionals diagnose a thymoma?

If a thymoma is not causing symptoms, health care professionals may identify it incidentally, meaning it is found on an imaging test of the chest (for example, X-ray, computerized tomography or CT scan) that is performed for another reason. If symptoms are present, health care providers may carry out chest X-rays or other imaging studies, such as CT scans or magnetic resonance imaging (MRI) scans or the combination of PET and CT scans, to identify the source of the symptoms.

While a mass in the anterior mediastinum can be seen on imaging studies, the definitive diagnosis can only be established when the mass is either removed surgically and examined by a pathologist or when a biopsy (surgical removal of a small portion of tissue for diagnostic purposes) is taken. Microscopic examination of the tumor biopsy tissue is necessary to confirm the diagnosis of thymoma or thymic carcinoma. Health care professionals classify the appearance of the tissue itself under the microscope as type A, B, or C based on its characteristics. Type C thymoma is thymic carcinoma and is quite rare.

What are the stages of thymoma?

The stage of a tumor refers to the extent to which it has spread to other local organs and tissues or to other parts of the body. There are two commonly used staging systems for thymoma, both of which classify the tumors as stage 1 through stage 4, depending upon the extent of spread and the degree of tissue invasion. While there are some differences in the two methods used to stage thymomas, a stage 1 tumor represents an encapsulated tumor (surrounded by a capsular structure) that has not spread outside of the thymus gland. Stage 4 represents the opposite extreme, in which invasion and spread to distant organs has occurred. Locally recurrent thymoma refers to the situation in which a tumor returns in the same area after its surgical removal.

What are types of treatment options for thymoma?

Surgery is the primary treatment for thymoma. The success of the surgery depends upon the particular characteristics of the tumor and its precise location; tumors have a higher surgical cure rate if physicians can remove them completely. If all evidence of disease is unable to be removed and microscopic, or tumor remains after surgery, then radiation therapy, chemotherapy, and targeted therapy drugs have been used in addition to surgical resection.

What is the prognosis for thymoma?

The prognosis (outcome) for thymoma is dependent upon the stage of the tumor as well as the ability to remove the tumor by surgery. Thymic carcinomas tend to behave more aggressively and have a worse prognosis than thymomas. Thymomas tend to be slow-growing tumors, and the prognosis is good to excellent for those with stage 1 or stage 2 thymoma. It is hard to estimate exact survival statistics based on stage because of the low numbers of people diagnosed with this tumor. In a German study of patients whose thymomas were completely removed by surgery, only 3% of the tumors recurred. Even 83% of patients with stage 3 thymoma were alive 10 years after diagnosis. The 10-year survival rate for stage 4 thymoma is approximately 47%. Overall, a majority of thymoma patients will live at least five years, while fewer than half or those with thymic carcinoma are expected to live that long.

Is it possible to prevent a thymoma?

Because the cause of thymoma is unknown and no risk factors have been identified, prevention of thymoma is not possible.