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tamoxifen, Nolvadex Side Effects (Weight Gain), Dosage & Dangers

What is tamoxifen (Soltamox)?

Tamoxifen is an anti-estrogen that prevents
the effects of
estrogens on tissues.

What brand names are available for tamoxifen (Soltamox)?

Soltamox is currently the only brand available for tamoxifen. Nolvadex brand has been discontinued.

Is tamoxifen (Soltamox) available as a generic drug?


Do I need a prescription for tamoxifen (Soltamox)?


Why is tamoxifen (Soltamox) prescribed to patients?

  • Tamoxifen is used for the treatment of invasive
    breast cancer in men and women, the most common type of
    breast cancer, following
    surgery and/or
    radiation and for preventing invasive

    breast cancer in women at
    high risk for developing it.

  • Tamoxifen also is used for the treatment of women
    following surgery and radiation for a less common type of
    breast cancer called
    carcinoma in situ (DCIS or intraductal carcinoma). Women who have had
    DCIS are at high risk for developing invasive breast cancer at a later date, and
    tamoxifen prevents development of the invasive cancer in almost half of the
    women during the first five years of treatment.
  • Occasionally, tamoxifen is used
    to stimulate

What are the side effects of tamoxifen (Soltamox)?


The most common side effects associated with tamoxifen are:

Serious side effects include:

  • Tamoxifen is associated with
    blood clots leading to
    deep vein thrombosis and
    pulmonary embolism.
  • Tamoxifen can cause
    of liver tests, reduced white blood cells,
    red blood cells, and platelets.
    Reduced platelets can lead to bleeding. Patients should keep appointments for
    blood work to monitor for these side effects. Patients should report any
    suspected side effects immediately, especially bleeding and yellowing of the


A lump in the breast is almost always cancer.
See Answer

What is the dosage for tamoxifen (Soltamox)?

  • The dose for metastatic breast cancer treatment, DCIS, and
    prevention of breast cancer is 10 mg twice daily or 20 mg once daily for 5
  • The dose for stimulation of ovulation is 5-40 mg twice daily for 4 days.
  • Tamoxifen can be taken with food.

Which drugs or supplements interact with tamoxifen (Soltamox)?

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Is tamoxifen (Soltamox) safe to use during pregnancy or while breastfeeding?

  • Tamoxifen should not be used
    during pregnancy because it
    can harm the fetus.
  • It is not known whether tamoxifen is excreted in breast milk. Tamoxifen causes a reduction in milk production. Women taking
    tamoxifen should not breastfeeding.

What else should I know about tamoxifen (Soltamox)?

What preparations of tamoxifen (Soltamox) are available?
  • Tablets: 10 and 20 mg. Solution: 10 mg/5 ml
How should I keep tamoxifen (Soltamox) stored?
  • Tamoxifen should be stored in a dry place at 15 C – 30 C (59 F – 86 F).
How does tamoxifen (Soltamox) work?
  • The precise mechanism of its action is
    unknown, but one possibility is that it binds and blocks estrogen receptors on
    the surface of cells, preventing estrogens from binding and activating the cell.
    It is used in patients for treating and preventing
    breast cancer.
When was tamoxifen (Soltamox) approved by the FDA?
  • Tamoxifen was
    approved by the FDA in December 1997.

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