What brand names are available for rivastigmine?
Exelon, Exelon Patch
Is rivastigmine available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for rivastigmine?
What are the uses for rivastigmine?
- Exelon and Exelon Patch is used for the treatment of
dementia of the Alzheimer's type or mild to moderate
What are the side effects of rivastigmine?
- The most common side effects Exelon and Exelon Patch are:
- Stomach pain
- Weight loss
- About one-half of patients who take Exelon and Exelon Patch develop
and about one-third vomit at least once, most commonly during the first few
weeks of treatment as the dose is slowly increased.
- Between one in five and one
in four patients lose weight during rivastigmine therapy (about 7 to 10 pounds,
- One in six patients experiences a
loss of appetite.
- About one in
fifty patients develops
dizziness. Overall, 15% of patients (between one in
seven and one in six) discontinue therapy due to side effects.
- Serious side effects include:
What is the dosage for rivastigmine?
- Exelon and Exelon Patch usually is taken twice daily with meals. Due to
gastrointestinal side effects that can be seen early in therapy, rivastigmine
therapy is generally started at a low dose.
Exelon and Exelon Patch for treating dementia associated with Alzheimer’s disease
- For treating dementia associated
with Alzheimer’s the starting dose is 1.5 mg twice daily.
- It is gradually
increased no more than once every two weeks.
- The goal usually is 3 to 6 mg twice
- If a patient develops severe gastrointestinal side effects such as upset
vomiting, he or she may need to stop taking rivastigmine for a few
doses and then start taking it again at the same dose or a lower dose.
Exelon and Exelon Patch for treating dementia associated with Parkinson’s disease
starting dose for treating dementia associated with
Parkinson’s disease is 1.5
mg orally twice daily.
- The dose may be increased every four weeks to 3 to 6 mg
- When using the patch the recommended starting dose is 4.6 mg/24
hours patch once daily.
- The patch should be replaced with a new one every day.
- The maximum dose is one 9.5 mg/24 hour patch. At least four weeks should elapse
before increasing the dose.
Which drugs or supplements interact with rivastigmine?
- Drugs with anticholinergic effects and which cross
into the brain, such as
benztropine (Cogentin), and trihexylphenidyl (Artane)
oppose the effects of rivastigmine and should be avoided during therapy with
Exelon and Exelon Patch.
- Unlike donepezil (Aricept),
Exelon and Exelon Patch does not cause the blood
levels of other medications to rise and increase their risk for side effects.
Is rivastigmine safe to take if I’m pregnant or breastfeeding?
- Studies in pregnant rats and rabbits with high doses of
Exelon and Exelon Patch failed to show effects on the offspring; however, no studies have
been performed in pregnant women. Therefore, physicians must weigh the potential
benefit of prescribing Exelon and Exelon Patch to pregnant women against the potential
risks to the fetus.
- It is not known if rivastigmine is secreted in
What else should I know about rivastigmine?
What preparations of rivastigmine are available?
- Capsules: 1.5 mg; 3 mg; 4.5 mg; 6 mg
- Patch: 4.6 mg/24 hours; 9.5 mg/24 hours; 13.3 mg/24 hours
How should I keep rivastigmine stored?
Capsules and solution should be stored at room temperature
15 C and 30 C (59 F and 86 F).