Physostigmine Salicylate Injection for Anticholinergic Syndrome: Side Effects & Dosage

What is Physostigmine, and how does it work?

Physostigmine Salicylate Injection is an antidote used to reverse the effect of drugs that cause anticholinergic syndrome.

What are the side effects of Physostigmine?

Common side effects of physostigmine salicylate include:

• nausea,
• vomiting,
• salivation,
• stomach cramps,
• diarrhea, and
• excessive sweating

What is the dosage for Physostigmine?

Past Anesthesia Care

• 0.5 to 1.0 mg intramuscularly or intravenously. Intravenous
  administration should be at a slow controlled rate of no more than 1 mg per
  minute.
• Dosage may be repeated at intervals of 10 to 30 minutes if desired patient response is not obtained.

Overdosage Of Drugs That Cause Anticholinergic

• 2.0 mg intramuscularly or intravenously at slow controlled rate (see
  above).
• Dosage may be repeated if life threatening signs, such as arrhythmia, convulsions or coma occurs.

Pediatric Dosage

• Recommended dosage is 0.02 mg/kg; intramuscularly or by slow intravenous injection, no more than 0.5 mg per minute.
• If the toxic effects persist, and there is no sign of cholinergic effects, the dosage may be repeated at 5 to 10 minute intervals until a therapeutic effect is obtained or a maximum of 2 mg dosage is attained.

What drugs interact with Physostigmine?

No Information Provided

Is Physostigmine safe to use while pregnant or breastfeeding?

• Safe use in pregnancy and lactation has not been established; therefore, use in pregnant women, nursing mothers or women who may become pregnant requires that possible benefits be weighed against possible hazards to mother and child.