High Potency Morphine Injection (Astramorph, Duramorph, Infumorph)

What is morphine high potency injection? What is morphine used for?

Morphine is a chemical found in the opium plant.
It is a narcotic (opiod) pain-reliever similar to hydrocodone, oxycodone,
methadone, fentanyl, and other opioids. Morphine, like other opioids, stimulates
receptors on nerves in the brain to increase the threshold to pain (increasing
the amount of stimulation it takes to feel pain) and reduce the perception of
pain (the perceived importance of the pain). The FDA approved injectable
morphine in October 1986.

What brand names are available for morphine high potency injection?

Astramorph, Duramorph, Infumorph, AVINza

Is morphine high potency injection available as a generic drug?

Yes

Do I need a prescription for morphine high potency injection?

Yes

What are the side effects of morphine high potency injection?

The most frequent adverse reactions of morphine include:

Other side effects include:

low blood pressure,
slowed heart rate,
itching,
fever,
confusion,
headache,
weakness, and
decreased oxygen delivery to the body.

Patients may also develop anemia with intrathecal injection, and pain
at the injection site. The elderly may be more sensitive to adverse effects.
Morphine has the potential to be habit forming. Tolerance and physical and
psychological dependence may occur with prolonged use. Seizures may result from
high doses. Overdoses may cause respiratory depression, coma, and death.

What is the dosage for morphine high potency injection?

Dosing is specific to the route of administration. In adults (at
least 18 years of age) the initial intravenous dose should be 2 to 10 mg per 70
kg of body weight over 24 hours. For epidural administration, 5 mg may be
administered initially, with a maximum dose of 10 mg over 24 hours. Initial
dosing for intrathecal administration should be 0.2 to 1 mg over 24 hours.

Which drugs or supplements interact with morphine high potency injection?

Combining alcohol and other sedatives with morphine can
lead to increased sedation and even cause confusion.

Fluoxetine (Prozac) may increase blood levels and the effect of morphine
leading to increased side effects.

Morphine should also be avoided in patients treated with monoamine oxidase
inhibitors (MAOI) due to enhance toxicity of morphine including confusion,
high
blood pressure, tremor, hyperactivity, coma, and death. Drugs in this class
include isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate),
selegiline (Eldepryl), and procarbazine (Matulane), and linezolid (Zyvox).
Morphine should not be administered within 14 days of stopping an MAOI.

QUESTION

Medically speaking, the term “myalgia” refers to what type of pain?
See Answer

Is morphine high potency injection safe to take if I’m pregnant or breastfeeding?

Morphine injection should only be given to pregnant women when no
other method of controlling pain is available and there are methods to monitor
the fetus. Newborns may exhibit withdrawal symptoms if chronic dosing is used.

Morphine is excreted in breast milk, however, the American
Academy of Pediatrics committee states that it is safe to use while nursing

What else should I know about morphine high potency injection?

What preparations of morphine high potency injection are available?

Solution 0.5, 2, 4, 5, 8, 10, 15, 25, and 50 mg/mL in 1, 2, 10, 20, 30, 50, and 250 mL ampules or vials. There is a preservative-free formulation for intrathecal and epidural (spinal) administration.

How should I keep morphine high potency injection stored?

Morphine injection solution should be protected from light and stored at room temperature, between 15 C to 30 C (59 F to 86 F).