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MSM Herbal Supplements Side Effects, Benefits, Uses & Dosage

What is MSM (methylsulfonylmethane ), and how does it work (mechanism of action)?

Methylsulfonylmethane (MSM) is also called dimethyl sulfone, DMSO2, methyl sulfone, and many other names. MSM is an organic sulfur found in fruits, vegetables, grains, and milk as well as the urine of animals. It is an oxidation product of dimethyl sulfoxide (DMSO) and a source of sulfur for producing the amino acids methionine and cysteine. MSM is a water soluble white, odorless, crystalline compound that contains 34% elemental sulfur.

Methylsulfonylmethane reduces pain, inflammation, and allergic reactions. It also has wound healing, dermatologic, and exercise performance increasing effects.

What other names are used for MSM (brands)?

Doctor's Best MSM, Natures Way MSM, and Now Foods MSM are brand names available for MSM.

Where can I buy MSM supplements?

You can find MSM herbal supplements in most pharmacies and health food stores.

What are the uses for MSM herbal supplements?

MSM has many uses. It is possibly effective for treating osteoarthritis, hemorrhoids, and rosacea, and may reduce the risk of developing exercise related muscle damage.

It also is used to treat:

What are the side effects of MSM supplements?

Common side effects associated with MSM include:

Other side effects include:


According to the USDA, there is no difference between a “portion” and a “serving.”
See Answer

What dosages of MSM supplements are available? How should I take them?

  • Typical adult dosages range from 500 to 8,000 mg.
  • MSM supplements may be taken daily with or after meals.

Which drugs or supplements interact with MSM?

There are no drug interactions listed for methylsulfonylmethane.

Are MSM supplements safe to take if I’m pregnant or breastfeeding?

  • Use of MSM during pregnancy has not been adequately evaluated.
  • It is not known whether MSM is excreted in breast milk.

What else should I know about MSM supplements?

What preparations of methylsulfonylmethane (MSM) are available?
  • Methylsulfonylmethane is available as tablets and powder, and is a component of many herbal products.
How should I keep methylsulfonylmethane (MSM) stored?
  • Methylsulfonylmethane should be stored at room temperature, 20 C to 25 C (68 F to 77 F).

MSM and other herbal supplements are not approved by the FDA for the prevention or treatment of medical diseases or conditions. Talk with your doctor or other health care professional, or a pharmacist before using this product.


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