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Vyvanse (lisdexamfetamine) for ADHD: Side Effects & Dosage

What is lisdexamfetamine (Vyvanse)? What are the uses for lisdexamfetamine (Vyvanse)?

Vyvanse is a central nervous system (CNS) stimulant used for the treatment of:

What are the side effects of lisdexamfetamine (Vyvanse)?

Common side effects of Vyvanse include:

Other important side effects of Vyvanse include:

Increased blood pressure, sudden death in patients with heart problems, strokes, and heart attacks have been associated with Vyvanse. Patients may experience new or worsening of psychiatric symptoms (for example, manic episodes, hearing voices, hallucinations) or worsening of aggressive behavior or hostility.

Vyvanse like other amphetamines may be abused. Amphetamines have been associated with tolerance, psychological dependence, and social disability. Stopping amphetamines suddenly may cause a withdrawal syndrome that includes extreme fatigue and mental depression. Therefore, there use should be discontinued by slowly reducing the dose.

Priapism, defined as painful and nonpainful penile erection lasting more than 4 hours, has been reported in pediatric and adult patients treated with stimulants. The erection usually resolves when the drug is stopped. Prompt medical attention is required in the event of suspected priapism.

What is the dosage for lisdexamfetamine (Vyvanse)?

  • The recommended starting dose of Vyvanse for treating ADHD in adults is 30 mg and for pediatric patients ages (6-12) it is 20 to 30 mg once daily in the morning. Doses may be increased by 10-20 mg/day at weekly intervals. The maximum dose is 70 mg daily.
  • The recommended dose for treating binge eating in adults is 50 to 70 mg daily. The starting dose is 30 mg/day and the dose is gradually increased by 20 mg at weekly intervals to reach the recommended daily dose.

Which drugs or supplements interact with lisdexamfetamine (Vyvanse)?

  • Monoamine oxidase inhibitor (MAOIs) antidepressants such as isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldepryl) and procarbazine (Matulane), slow the elimination of amphetamines in the body. This increases the concentration of amphetamines and their effect. This can cause serious elevations in blood pressure (hypertensive crisis) with headaches, other signs of hypertensive crisis, and even fatal reactions. Vyvanse should not be administered until 14 days after MAOIs have been discontinued in order to allow the effects of the MAOIs to dissipate.
  • Amphetamines increase the effect of norepinephrine. Combining both drugs may lead to serious cardiovascular toxicity.

Is lisdexamfetamine (Vyvanse) safe to take if I’m pregnant or breastfeeding?

  • There are no adequate studies of Vyvanse in pregnant women. Amphetamines may cause premature delivery, low birth weight, and withdrawal symptoms in infants born to mothers who are dependent on amphetamines.
  • Amphetamines are excreted in breast milk. Mothers taking amphetamines should not breastfeed.

What else should I know about lisdexamfetamine (Vyvanse)?

What preparations of lisdexamfetamine are available?

Capsules: 10, 20, 30, 40, 50, 60, and 70 mg

How should I keep lisdexamfetamine stored?

Vyvanse should be stored at room temperature, 15 C to 30 C (59 F to 86 F), and protected from light.


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