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Synvisc (hylan G-F 20): Arthritis Joint Injection Side Effects & Dosage

What is hylan G-F 20 (Synvisc, Synvisc One), and how does it work (mechanism of action)?

What is hylan G-F 20 (Synvisc, Synvisc One)?

Hylan G-F 20 (Synvisc, Synvisc One) is an injectable fluid that is used to treat osteoarthritis (OA) of the knee. Osteoarthritis is a type of arthritis in which the joints of the body degenerate and become painful and stiff. Osteoarthritis is the most common form of arthritis. Almost 10 million Americans suffer from the disease. Most people with OA are those 45 years old, and women. More women have OA than men.

How does Synvisc work?

Joints contain a fluid, called synovial fluid, which acts as a lubricant and shock absorber. Patients with osteoarthritis have synovial fluid that is thinner than normal, and, therefore, it is less effective as a lubricant and shock-absorber. Synvisc is an elastic fluid that is made from a substance called hyaluronan, that is found in normal joint fluid. Hyaluronan is the key substance in joint fluid that provides the shock-absorbing quality to the fluid, and it is essential for the proper functioning of joints. When Synvisc is injected into the knee of a patient with osteoarthritis, the drug helps to restore the shock-absorbing effect of the fluid within the knee. This can reduce pain, resulting in a more active lifestyle.

What brand names are available for hylan G-F 20?

Synvisc and Synvisc-One are the brand names available for this generic drug.

Do I need a prescription for Synvisc?

Yes, you need a prescription for this hylan G-F 20.

What are the uses for Synvisc?

Synvisc is used for treating pain caused by osteoarthritis of the knee.

What are the side effects of Synvisc?

About 1 in 14 persons experience pain or swelling in the injected knee, and one third of those who do, need to have fluid removed from the knee.

Common side effects include:

Other side effects include:

  • Injection site pain
  • Injection site stiffness
  • Injection site redness
  • Skin rash
  • Itching
  • Facial flushing
  • Facial swelling


What joints are most often affected by osteoarthritis?
See Answer

Which drugs or supplements interact with Synvisc?

There are no known drug interactions with Sinvisc.

What’s the dosage for Synvisc and Synvisc One, and how is the injection given?

  • Synvisc is injected into the knee by a doctor or other health care professional. A course of treatment consists of three injections with each injection seven days apart when using Synvisc.
  • Alternatively Synvisc-One, which contains all 3 doses (48 mg/ 6 ml) can be injected once as a single injection.

Most people experience the greatest amount of relief from pain 8 to 12 weeks after beginning treatment. Some patients will require more than one course of treatment.

Is this drug safe to take if I’m pregnant or breastfeeding?

  • No adequate studies have been done in pregnant women with this drug.
  • The risks of Synvisc during breastfeeding are not known. It is not known if Synvisc is excreted into breast milk.

What else should I know about this drug?

What preparations of Synvisc are available?

Injection: 16 mg/2 ml, 48 mg/6 ml

How should I keep Synvisc stored?

Synvisc should be stored at room temperature, below 86 F (30 C). Any unused solution should be thrown out. It should not be frozen.


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