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HomemedicationsGiapreza (angiotensin II) for Septic Shock: Side Effects & Interactions

Giapreza (angiotensin II) for Septic Shock: Side Effects & Interactions

What is Giapreza and how does it work?

  • Giapreza (angiotensin II) is a vasoconstrictor to increase blood pressure in adults with septic or other distributive shock.
  • Angiotensin II is a naturally occurring peptide hormone of the renin-angiotensin-aldosterone system (RAAS) that causes vasoconstriction and an increase in blood pressure.
  • Giapreza is a sterile, aqueous solution of synthetic human angiotensin II for intravenous administration by infusion.

What are the side effects of Giapreza?

Common side effects of Giapreza include:

What is the dosage for Giapreza?

  • The recommended starting dosage of Giapreza is 20 nanograms (ng)/kg/min via continuous intravenous infusion.
  • Administration through a central venous line is recommended.
  • Monitor blood pressure response and titrate Giapreza every 5 minutes by increments of up to 15 ng/kg/min as needed to achieve or maintain target blood pressure.
  • Do not exceed 80 ng/kg/min during the first 3 hours of treatment.
  • Maintenance doses should not exceed 40 ng/kg/min.
  • Doses as low as 1.25 ng/kg/min may be used.
  • Once the underlying shock has sufficiently improved, down-titrate every 5 to 15 minutes by increments of up to 15 ng/kg/min based on blood pressure.

What drugs interact with Giapreza?

  • Angiotensin Converting Enzyme (ACE) Inhibitors Concomitant use of angiotensin converting enzyme (ACE) inhibitors may increase the response to Giapreza.
  • Angiotensin II Receptor Blockers (ARB) Concomitant use of angiotensin II receptor blockers (ARBs) may decrease the response to Giapreza.

Is Giapreza safe to take when pregnant or breastfeeding?

  • The published data on angiotensin II use in pregnant women are not sufficient to determine a drug-associated risk of adverse developmental outcomes.
  • It is not known whether Giapreza is present in human milk.
  • No data are available on the effects of angiotensin II on the breastfed child or the effects on milk production.

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