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fludrocortisone (Florinef) Uses, Side Effects & Dosage

What is fludrocortisone? What is fludrocortisone used for?

Fludrocortisone is a man-made oral corticosteroid. It is derived from hydrocortisone, but is more potent than hydrocortisone. The effects of fludrocortisone including its effect on electrolyte balance and carbohydrate metabolism are stronger and prolonged in comparison to hydrocortisone.

Florinef (fludrocortisone) Acetate is indicated as partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenogenital syndrome.

Fludrocortisone mimics the actions of aldosterone which is a steroid that is naturally produced by the body. The physiological effects of fludrocortisone are dose dependent. Small oral doses of fludrocortisone cause an increase in blood pressure, sodium retention, and increases urinary potassium excretion. Larger doses of fludrocortisone inhibit the secretion of hormones from the adrenal gland. Fludrocortisone was initially approved by the US Food and Drug Administration (FDA) in 1954. The first generic fludrocortisone tablet was approved by the FDA in March 2002.

Is fludrocortisone available as a generic drug?

Yes

Do I need a prescription for fludrocortisone?

Yes

What are the side effects of fludrocortisone?

Reported side effects include:

Fludrocortisone may increase the risk of infections.

What is the dosage for fludrocortisone?

  • Addison’s disease: The usual recommended dose is 0.1 mg by mouth once
    daily without regard to food. Dose should be reduced to 0.05 mg daily if
    hypertension develops. Maintenance dosage range is 0.1 to 0.2 mg 3 times weekly.
    Fludrocortisone is preferably administered with cortisone (10 to 37.5 mg daily)
    or hydrocortisone (10 to 30 mg daily).
  • Salt losing adrenogenital syndrome: The recommended dose is 0.1 to 0.2 mg
    daily.

Which drugs or supplements interact with fludrocortisone?

: Antacids and bile acid sequestrants (for example, cholestyramine
[Questran, Questran Light],
colestipol
[Colestid], and
colesevelam
[Welchol]) may decrease the absorption of oral
corticosteroids.

Oral corticosteroids may decrease the effectiveness of
diabetes medications.

Medications that may decrease blood levels of corticosteroids include
barbiturates, isoniazid (Nydrazid, Laniazid, INH), mitotane (Lysodren), rifampin
(Rifadin, Rifadin IV), aminoglutethimide (Cytadren), primidone (Mysoline), and
others.

Medications that may increase blood levels of corticosteroids include aprepitant (Emend), strong CYP3A4 inhibitors, estrogen derivatives, mifepristone
(Mifeprex), and others.

Corticosteroids may increase the risk of adverse effects associated with live
vaccine administration.

Is fludrocortisone safe to take if I’m pregnant or breastfeeding?

Although information specific to fludrocortisone is not
available, corticosteroids are excreted in
breast milk. Due to the risk of
adverse effects in the infant, fludrocortisone should be used cautiously in
nursing mothers.

What else should I know about fludrocortisone?

What preparations of fludrocortisone are available?

Tablets: 0.1 mg

How should I keep fludrocortisone stored?

Tablets should be stored at room temperature between 2 C and 8 C (36
F and 46 F).

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