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Here are the differences between the Moderna and Pfizer-BioNTech COVID-19 vaccines.
COVID-19 vaccines were developed within a very short span, and they were found to be effective in most of the vaccinated population. Various varieties of vaccines were developed by different nations after conducting extensive research on the SARS-CoV-2 virus.
The U.S. Food and Drug Administration (FDA) has approved three vaccines so far, and Moderna and Pfizer-BioNTech vaccines are among them.
- Moderna and Pfizer vaccines were made using messenger RNA (mRNA).
- After entering the body, the mRNA provokes your immune system.
- As a response to these vaccines, your body produces an immune response against spike protein—a special protein present on the surface of the SARS-CoV-2 virus.
Although Moderna and Pfizer vaccines are made using the same technology and have near similar effects on the body, there are certain differences among them that have been highlighted in the following table.
mRNA vaccine
mRNA vaccine
The vaccine provides a tiny piece of genetic code from the SARS-CoV-2 virus to host immune cells and provoke them to produce antibodies against spike protein
The vaccine provides a tiny piece of genetic code from the SARS-CoV-2 virus to host immune cells and provoke them to produce antibodies against spike protein
FDA-approved
FDA-approved
December 18, 2020
December 11, 2020
18 years and older
12 years and older
18 years and older
5 years and older
Two doses 28 days apart
Two doses 21 days apart:
- Two 10 mcg doses for individuals who are 5 to 11 years
- Two 30 mcg doses for individuals who are 12 years and older
A single dose is given after:
- 28 days in immunocompromised people
- Six months in people who are fully vaccinated with two doses
A single dose is given after:
- 28 days in immunocompromised people
- Six months in people who are fully vaccinated with two doses
14 days after the second dose
14 days after the second dose
Effectiveness
(may vary as clinic trials are going on)
- 94 percent in age groups 18 years and older
- 90 percent of people with comorbidities such as diabetes and obesity
- 91 percent in age groups 16 years and older
- 89 percent of people with comorbidities such as obesity and diabetes
- 100 percent in age groups 12 to 15 years
- 91 percent in age groups 2 to 11 years
Against severe COVID-19
Against severe COVID-19
- Alpha variant
- Beta variant
- Delta variant
- Eta variant
- Kappa variant
- Alpha variant
- Beta variant
- Pain in the site of injection
- Headache
- Fatigue
- Chills
- Fever
- Joint pain
- Nausea
- Muscle pain
- Feeling unwell
- Swelling of the lymph nodes
Rare:
- Heart issues
- Breathlessness
- Rapid heart rate
- Anaphylaxis
- Pain in the site of injection
- Headache
- Fatigue
- Chills
- Fever
- Joint pain
- Nausea
- Muscle pain
- Feeling unwell
- Swelling of the lymph nodes
Rare:
- Heart issues
- Breathlessness
- Rapid heart rate
- Anaphylaxis
Possible inflammation of the heart such as
- Myocarditis
- Pericarditis
Possible inflammation of the heart such as
- Myocarditis
- Pericarditis
Under phase III clinical trials
Under phase III clinical trials
Free of cost
Free of cost
Are COVID-19 vaccines safe?
The U.S. Food and Drug Administration has approved COVID-19 vaccines as safe for humans after conducting various clinical trials on animals and healthy humans.
Every day, hundreds of thousands of physicians, nurses, elders, and others are immunized to show that the vaccines are safe. To date, millions of citizens have been fully vaccinated across the country.
Booster doses that are given to fully vaccinated people make their immunity strong against the SARS-Cov-2 virus.
