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Homebreast cancerConjupri (levamlodipine) for Hypertension: Side Effects & Dosage

Conjupri (levamlodipine) for Hypertension: Side Effects & Dosage

What is Conjupri, and how does it work?

Conjupri is a prescription medicine used to treat high blood pressure (hypertension) in adults and pediatric patients 6 years and older.
Conjupri can be used by itself or with other high blood pressure medicines.

It is not known if
Conjupri is safe and effective in children less than 6 years of age.

What are the side effects of Conjupri?

Conjupri may cause serious side effects, including:

The most common side effects of
Conjupri include:

These are not all of the possible side effects of

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the dosage for Conjupri?


  • The usual initial antihypertensive oral dose of levamlodipine is 2.5 mg once daily, and the maximum dose is 5 mg once daily.
  • Small, fragile, or elderly patients, or patients with hepatic insufficiency may be started on 1.25 mg once daily and this dose may be used when adding levamlodipine to other antihypertensive therapy.
  • Adjust dosage according to blood pressure goals.
  • In general, wait 7 to 14 days between titration (decreasing dosage) steps. Titrate more rapidly, however, if clinically warranted, provided the patient is assessed frequently.


  • The effective antihypertensive oral dose in pediatric patients ages 6-17
    years is 1.25 mg to 2.5 mg once daily.
  • Doses in excess of 2.5 mg daily have not been studied in pediatric


Salt and sodium are the same.
See Answer

What drugs interact with Conjupri?

Impact Of Other Drugs On Amlodipine

CYP3A Inhibitors
  • Co-administration with CYP3A inhibitors (moderate and strong) results in
    increased systemic exposure to amlodipine and may require dose reduction.
  • Monitor for symptoms of hypotension and edema when amlodipine is co-administered
    with CYP3A inhibitors to determine the need for dose adjustment.
CYP3A Inducers
  • No information is available on the quantitative effects of CYP3A inducers on amlodipine.
  • Blood pressure should be closely monitored when amlodipine is co-administered with CYP3A inducers.

Impact Of Amlodipine On Other Drugs

  • Co-administration of simvastatin with amlodipine increases the systemic exposure
    of simvastatin.
  • Limit the dose of simvastatin in patients on amlodipine to 20 mg
  • Amlodipine may increase the systemic exposure of cyclosporine or tacrolimus when
  • Frequent monitoring of trough blood levels of cyclosporine and
    tacrolimus is recommended and adjust the dose when appropriate.

Is Conjupri safe to use while pregnant or breastfeeding?

  • The limited available data based on post-marketing reports with amlodipine use in pregnant women are not sufficient to inform a drug-associated risk for major birth defects and miscarriage.
  • There are risks to the mother and fetus associated with poorly controlled hypertension in pregnancy.
  • Limited available data from a published clinical lactation study reports that amlodipine is present in human milk at an estimated median relative infant dose of 4.2%.
  • No adverse effects of amlodipine on the breastfed infant have been observed.
  • There is no available information on the effects of amlodipine on milk production.

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