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Atovaquone/Proguanil (Malarone) Uses Side Effects & Dosage

What is atovaquone-proguanil, and how does it work (mechanism of action)?

Atovaquone and proguanil is an anti-malarial medication. Atovaquone blocks mitochondrial electron transfer and thereby the production of energy for use by the parasites. Proguanil is metabolized into its active metabolite, cycloguanil, which blocks dihydrofolate reductase and enzymes required for making pyrimidine which is a chemical needed for production of DNA.

What brand names are available for atovaquone-proguanil-oral?


Is atovaquone-proguanil-oral available as a generic drug?


Do I need a prescription for atovaquone-proguanil-oral?


What are the side effects of atovaquone-proguanil?

Common side effects of atovaquone and proguanil are:

What is the dosage for atovaquone-proguanil?

Prevention of malaria:

Which drugs or supplements interact with atovaquone-proguanil?

Combining atovaquone/proguanil with tetracycline can lower atovaquone levels in the body, leading to lack of effectiveness of the antimalarial medication.

Concomitant use of atovaquone/proguanil and rifampin or rifabutin can lower atovaquone levels approximately 50% and 34%, reducing effectiveness of malarial medication.

Concomitant use of atovaquone/proguanil and metoclopramide (Reglan, Reglan ODT, Metozol ODT, Octamide) may lower the amount of atovaquone that the body can absorb, leading to lack of effectiveness.


Bowel regularity means a bowel movement every day.
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Is atovaquone-proguanil safe to take if I’m pregnant or breastfeeding?

There are no adequate studies of atovaquone and proguanil to determine safe and effective use in pregnant women.

It is not known if atovaquone enters breast milk, but proguanil may enter breast milk in trace amounts. It is best to exercise caution before using these drugs in nursing mothers.

What else should I know about atovaquone-proguanil?

What preparations of atovaquone-proguanil-oral are available?

Atovaquone and proguanil tablets are available in two combination strengths: 250/100 mg (adults) and 62.5/25 mg (pediatric).

How should I keep atovaquone-proguanil-oral stored?

Store Atovaquone and proguanil tablets should be stored between 15 C to 30 C (59 F to 86 F).


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