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lixisenatide (Adlyxin): Type 2 Diabetes Drug Side Effects & Dosage

What is lixisenatide, and how does it work?

  • Lixisenatide is an injectable drug that reduces the
    level of sugar (glucose) in the blood. It is used for the treatment type 2 diabetes
    and is similar to

  • Lixisenatide belongs in a class of drugs
    called incretin mimetics because these drugs mimic the effects of incretins.
    Incretins, such as human-glucagon-like peptide-1 (GLP-1), are hormones that are
    produced and released into the blood by the intestine in response to food. GLP-1
    increases the secretion of insulin from the pancreas, slows absorption of
    glucose from the gut, and reduces the action of glucagon. (Glucagon is a hormone
    that increases glucose production by the liver.) All three of these actions
    reduce levels of glucose in the blood. In addition, GLP-1 reduces appetite.
    Lixisenatide is a synthetic (man-made) hormone that resembles and acts like
    GLP-1. In studies, lixisenatide treated patients achieved lower blood glucose
    levels and experienced weight loss.

What brand names are available for lixisenatide?

Adlyxin is the brand name available for lixisenatide available in the US.

Is lixisenatide available as a generic drug?

No

Do I need a prescription for lixisenatide?

Yes

What are the uses for lixisenatide?

What are the side effects of lixisenatide?

Common side effects of include:

Other possible side effects of include:

Possible serious side effects of include:

What is the dosage for lixisenatide?

  • The recommended starting dose of Adlyxin is 10 mcg
    injected under the skins (subcutaneously) once daily for 14 days.
  • The dose
    should be increased on day 15 to the maintenance dose of 20 mcg once daily.

Which drugs or supplements interact with lixisenatide?

  • Adlyxin slows down transit of food and drugs
    through the intestine and, therefore, may reduce the absorption of drugs that
    are taken by mouth. Caution should be used when combining Adlyxin with oral
    medications that have a narrow therapeutic ratio or that require careful
    monitoring. If these medications are to be taken with food they should be taken
    with a meal or snack when Adlyxin is not administered.
  • Oral medications
    such as antibiotics, or medications, for example acetaminophen (Tylenol) whose
    effects shouldn't be delayed should be taken at least 1 hour before Adlyxin
    injection.
  • Oral contraceptives should be taken at least 1 hour before
    Adlyxin administration or at least 11 hours after an injection of
    Adlyxin.
  • Combining Adlyxin with insulin or drugs that stimulate release of
    insulin, for example, glyburide (Micronase, Diabeta, Glynase, Prestab) may
    increase the occurrence of low blood sugar (hypoglycemia). The dose of insulin
    or the insulin release stimulating drug should be reduced.

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Is lixisenatide safe to use during pregnancy or while breastfeeding?

  • There are no adequate studies of lixisenatide in
    pregnant women. Most experts agree that insulin is the drug of
    choice in pregnant women with diabetes.
  • There are no adequate studies of lixisenatide in
    nursing mothers, and it is not known whether
    this drug is
    excreted in human breast milk.

What else should I know about lixisenatide?

What preparations of lixisenatide are available?
  • Injection (Prefilled Pen): 50, 100 mcg/mL
How should I keep lixisenatide stored?
  • Adlyxin pen should be kept in the package to protect it from
    light and it should be stored in a refrigerator at 2 C to 8 C (36 F to 46 F) prior to
    use.
  • It should not be frozen.
  • After first use, it should be stored below 30 C (86 F).
  • The pen cap should be
    replaced after each use to protect it from light.
  • The pen should discarded 14
    days after first use.
When was lixisenatide approved by the FDA?
  • The FDA approved lixisenatide in July 2016.
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