What Are the Rarest Cancers? Top 10 Cancer Chart

cancer
Rare cancer can be challenging for patients, doctors, and scientists due to the limited information available.

Rare cancer occurs in fewer than 15 out of 100,000 people every year.

Some of the characteristics of the rarest cancer are:

  • Difficult to prevent, diagnose, and treat than the more common cancers
  • Research is difficult because there are a few cases
  • They make up just over a quarter of all cancers
  • Rare cancer can cause a quarter of all cancer deaths
  • Finding a new treatment for a rare cancer is extremely challenging

Rare cancer chart

The rarest types of cancer are presented in the table below.

Table. Some of the rarest cancer and their occurrence, survival rate, and the body parts affected Types of rare cancer Number of people affected every year The area of the body affected Symptoms Is it treatable? Survival rate

Hyalinizing clear cell carcinoma of minor salivary gland tumor
51 cases

  • Salivary glands
  • Tongue
  • Palate
  • Swelling
  • Difficulty swallowing
  • Ulceration

Treatable with surgery
High survival rate

Heart cancer
Reported one to two patients per year
Heart

  • Heart failure
  • Irregular heartbeat

Yes
The 5-year survival rate is 17 percent

Ewing’s sarcoma
3 per 1 million people

  • Bone or soft tissue of the pelvis
  • The femur (thigh bone)
  • The humerus (upper arm bone)
  • The ribs
  • The mandible (jaw)
  • The clavicle (collar bone)
  • A lump near the skin that feels warm and soft to the touch
  • Persistent low fever
  • Limping because the legs hurt
  • Bone pain that worsens while exercising or during the night
  • Broken bones that happen without an injury
  • Weight loss
  • Feeling tired constantly
  • Paralysis or loss of bladder control if the tumor occurs near the spine

Yes
The 5-year survival rate for tumors that have not spread is about 70 percent and 30 percent for tumors that have spread to other locations

Thymic carcinoma
400 cases per year
Thymus gland

  • A cough that does not go away
  • Shortness of breath
  • Chest pain
  • A hoarse voice
  • Swelling in the face, neck, upper body, or arms

Yes
The 5-year survival rate is between 30 and 50 percent

Wilms’ tumor
1 in 10,000 children each year (about 500 to 650 in the United States)
Kidneys

  • An abdominal mass
  • Abdominal swelling
  • Abdominal pain
  • Fever
  • Blood in the urine
  • Nausea or vomiting or both
  • Constipation
  • Loss of appetite
  • Shortness of breath
  • High blood pressure

Yes
High: The 5-year survival rate is about 90 percent

Merkel cell carcinoma
About 2000 cases in the United States each year
Skin cancer typically found on the face, head, or neck

  • Painless, shiny lumps of the skin
  • Red, pink lumps

Yes
The 10-year survival rate of about 57 percent (about 71 percent if caught early)

Glioblastoma (a type of brain tumor)
0.59 to 5 cases per 100,000 people
Found in the brain

  • Headaches
  • Nausea
  • Memory loss
  • Difficulty balancing 
  • Vision problems

Yes
Low: People live less than a year after diagnosis

Hepatoblastoma
50 to 75 new cases
Liver

  • Pain or swelling in the abdomen
  • Loss of appetite
  • Weight loss

Yes
The five-year survival rate in children is 81.5 percent

Male breast cancer
About 2550 cases each year in the United States
Male breast tissue

  • Redness or sores on the chest or nipple area
  • An inverted nipple (nipple is pulled inward)
  • Discharge from the nipple
  • Redness or scaling of the skin covering the breast
  • Thickening of the breast tissue
  • Nipple pain
  • Enlarged lymph nodes under the arm

Yes
The five-year survival rate is 84 percent

Fibrosarcoma
5 per 1 million
A type of soft tissue cancer that begins in fibrous tissue, which holds bones, muscles, and other organs in place

  • Pinched nerve
  • Unusual swelling
  • Unintended weight loss
  • A painful soft lump

Yes
The five-year survival rate is 40 to 60 percent

Why is rare cancer challenging?

Rare cancer can be challenging for patients, doctors, and scientists due to the limited information available.

For patients

  • The time taken to identify any symptoms and the time taken by the doctor to identify the type of cancer can be time-consuming.
  • Because there is limited information available on the rarest cancer, it would be difficult to find doctors who are aware of cancer and its treatment.
  • They might experience a dilemma if the doctors do not agree on how to treat cancer.
  • There might be a need to travel away from home to a distant place to get appropriate treatment for cancer.

For doctors

  • It would be difficult for them to explain to their patients the outcome of the disease and treatment modalities due to the limited information available.
  • They may have a lack of experience or training to treat this type of cancer.
  • Lack of availability of experts in rare cancer to whom they can ask their concerns or refer the patient.

For scientists

  • Due to lack of information, they may not be sure about drugs that could help treat this type of cancer.
  • Lack of animal or cell models of rare cancer to test their ideas.
  • Insufficient tumor samples from rare cancer patients are available to move further in the research.
  • Finding enough patients with rare cancers is difficult. They are extremely important to execute the ideas about the drugs that could probably treat rare cancer.

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What Are the Rarest Cancers? Top 10 Cancer Chart

cancer
Rare cancer can be challenging for patients, doctors, and scientists due to the limited information available.

Rare cancer occurs in fewer than 15 out of 100,000 people every year.

Some of the characteristics of the rarest cancer are:

  • Difficult to prevent, diagnose, and treat than the more common cancers
  • Research is difficult because there are a few cases
  • They make up just over a quarter of all cancers
  • Rare cancer can cause a quarter of all cancer deaths
  • Finding a new treatment for a rare cancer is extremely challenging

Rare cancer chart

The rarest types of cancer are presented in the table below.

Table. Some of the rarest cancer and their occurrence, survival rate, and the body parts affected Types of rare cancer Number of people affected every year The area of the body affected Symptoms Is it treatable? Survival rate

Hyalinizing clear cell carcinoma of minor salivary gland tumor
51 cases

  • Salivary glands
  • Tongue
  • Palate
  • Swelling
  • Difficulty swallowing
  • Ulceration

Treatable with surgery
High survival rate

Heart cancer
Reported one to two patients per year
Heart

  • Heart failure
  • Irregular heartbeat

Yes
The 5-year survival rate is 17 percent

Ewing’s sarcoma
3 per 1 million people

  • Bone or soft tissue of the pelvis
  • The femur (thigh bone)
  • The humerus (upper arm bone)
  • The ribs
  • The mandible (jaw)
  • The clavicle (collar bone)
  • A lump near the skin that feels warm and soft to the touch
  • Persistent low fever
  • Limping because the legs hurt
  • Bone pain that worsens while exercising or during the night
  • Broken bones that happen without an injury
  • Weight loss
  • Feeling tired constantly
  • Paralysis or loss of bladder control if the tumor occurs near the spine

Yes
The 5-year survival rate for tumors that have not spread is about 70 percent and 30 percent for tumors that have spread to other locations

Thymic carcinoma
400 cases per year
Thymus gland

  • A cough that does not go away
  • Shortness of breath
  • Chest pain
  • A hoarse voice
  • Swelling in the face, neck, upper body, or arms

Yes
The 5-year survival rate is between 30 and 50 percent

Wilms’ tumor
1 in 10,000 children each year (about 500 to 650 in the United States)
Kidneys

  • An abdominal mass
  • Abdominal swelling
  • Abdominal pain
  • Fever
  • Blood in the urine
  • Nausea or vomiting or both
  • Constipation
  • Loss of appetite
  • Shortness of breath
  • High blood pressure

Yes
High: The 5-year survival rate is about 90 percent

Merkel cell carcinoma
About 2000 cases in the United States each year
Skin cancer typically found on the face, head, or neck

  • Painless, shiny lumps of the skin
  • Red, pink lumps

Yes
The 10-year survival rate of about 57 percent (about 71 percent if caught early)

Glioblastoma (a type of brain tumor)
0.59 to 5 cases per 100,000 people
Found in the brain

  • Headaches
  • Nausea
  • Memory loss
  • Difficulty balancing 
  • Vision problems

Yes
Low: People live less than a year after diagnosis

Hepatoblastoma
50 to 75 new cases
Liver

  • Pain or swelling in the abdomen
  • Loss of appetite
  • Weight loss

Yes
The five-year survival rate in children is 81.5 percent

Male breast cancer
About 2550 cases each year in the United States
Male breast tissue

  • Redness or sores on the chest or nipple area
  • An inverted nipple (nipple is pulled inward)
  • Discharge from the nipple
  • Redness or scaling of the skin covering the breast
  • Thickening of the breast tissue
  • Nipple pain
  • Enlarged lymph nodes under the arm

Yes
The five-year survival rate is 84 percent

Fibrosarcoma
5 per 1 million
A type of soft tissue cancer that begins in fibrous tissue, which holds bones, muscles, and other organs in place

  • Pinched nerve
  • Unusual swelling
  • Unintended weight loss
  • A painful soft lump

Yes
The five-year survival rate is 40 to 60 percent

Why is rare cancer challenging?

Rare cancer can be challenging for patients, doctors, and scientists due to the limited information available.

For patients

  • The time taken to identify any symptoms and the time taken by the doctor to identify the type of cancer can be time-consuming.
  • Because there is limited information available on the rarest cancer, it would be difficult to find doctors who are aware of cancer and its treatment.
  • They might experience a dilemma if the doctors do not agree on how to treat cancer.
  • There might be a need to travel away from home to a distant place to get appropriate treatment for cancer.

For doctors

  • It would be difficult for them to explain to their patients the outcome of the disease and treatment modalities due to the limited information available.
  • They may have a lack of experience or training to treat this type of cancer.
  • Lack of availability of experts in rare cancer to whom they can ask their concerns or refer the patient.

For scientists

  • Due to lack of information, they may not be sure about drugs that could help treat this type of cancer.
  • Lack of animal or cell models of rare cancer to test their ideas.
  • Insufficient tumor samples from rare cancer patients are available to move further in the research.
  • Finding enough patients with rare cancers is difficult. They are extremely important to execute the ideas about the drugs that could probably treat rare cancer.

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