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What is clonidine (Kapvay extended-release), and how does it work (mechanism of action)?
Kapvay is an oral medication used to treat
attention deficit hyperactivity
disorder (ADHD) in children and
adolescents. This drug has been used to reduce
blood pressure in adults for many years but has been approved for another
indication by the FDA. Kapvay works by stimulating alpha-2 receptors in the brain. This may reduce
hyperactivity symptoms by acting on parts of the brain that control emotion,
attention and behavior. However the exact mechanism in treating ADHD is not
known. The FDA approved Kapvay for pediatric patients aged 6–17 years in
September 2010.
What brand names are available for clonidine (Kapvay extended-release)?
Kapvay (extended release)
Is clonidine (Kapvay extended-release) available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for clonidine (Kapvay extended-release)?
Yes
What are the side effects of clonidine (Kapvay extended-release)?
The most common side effects associated with Kapvay are
drowsiness, fatigue, cough, runny nose, and sore throat. Kapvay can also cause
dry mouth, hallucinations, constipation and insomnia. Reductions in blood
pressure and heart rate, which can be severe, have also been reported.
What is the dosage for clonidine (Kapvay extended-release)?
Kapvay tablets should be swallowed whole, and should not be broken,
chewed or crushed before swallowing. Kapvay tablets can be taken with or without
food.
The recommended starting dose is 0.1 mg tablet once a day at bedtime. Doses
may be increased by 0.1 mg per day every 7 days. In this case, doses should be
given twice a day (either split equally, or the higher dose given at bedtime).
The maximum daily dose of Kapvay is 0.4 mg per day.
Which drugs or supplements interact with clonidine (Kapvay extended-release)?
: Kapvay should not be used with alcohol or other sedating
drugs such as lorazepam (Ativan) due to increased risk of drowsiness.
Combining Kapvay with medications that can affect heart rate such as
diltiazem and atenolol (Tenormin) can lead to a severe decrease in heart rate.
Tricyclic antidepressants such as amitriptyline
(Elavil, Endep) can reduce the
antihypertensive effects of Kapvay by blocking its receptors.
Kapvay should not be combined with other clonidine containing medications
such as Catapres. Kapvay should be used carefully in patients taking other
medications that reduce blood pressure due to risk of excessive blood pressure
reduction.
Is clonidine (Kapvay extended-release) safe to take if I’m pregnant or breastfeeding?
Kapvay is secreted into breast milk and should be used
cautiously in women who are
breastfeeding.
What else should I know about clonidine (Kapvay extended-release)?
What preparations of clonidine (Kapvay extended-release) are available?
Tablets: 0.1, 0.2 mg (extended release)
How should I keep clonidine (Kapvay extended-release) stored?
Kapvay tablets should be stored at room temperature 20 C to 25 C (68
F to 77 F) and protected from light.